Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, Hungary.
Anticancer Res. 2010 Feb;30(2):451-4.
Chemoprevention is a promising new approach to cancer prevention. Since the beginning of chemoprevention studies, short-term in vitro models used in the study of carcinogenesis have been applied in the identification of antitumor-promoting agents.
The lignans threo-4,4'-dihydroxy-3-methoxylignan, (-)-dihydroguaiaretic acid, 4'-hydroxy-3,3',4-trimethoxylignan, 3,3',4,4'-tetramethoxylignan, 4,4'-diacetyl-3,3'-dimethoxylignan, talaumidin, heliobuphthalmin, (-)-dihydro-cubebin, and hinokinin were evaluated for their ability to inhibit human cytomegalovirus (HCMV) IE-antigen expression in lung cancer cells (A549).
Most of the evaluated compounds reduced IE-antigen expression of HCMV, the best result being obtained with 4,4'-dihydroxy-3-methoxylignan. However, a dose-dependent significant increase of IE-antigen expression was found for the derivative (-)-dihydrocubebin.
The results of this study suggest that some of these lignans might be valuable as potential cancer chemopreventive agents.
化学预防是癌症预防的一种很有前途的新方法。自从化学预防研究开始以来，用于致癌研究的短期体外模型已被应用于鉴定抗肿瘤促进剂。
木脂素 threo-4,4'-二羟基-3-甲氧基木脂素、(-)-二氢愈创木酸、4'-羟基-3,3',4-三甲氧基木脂素、3,3',4,4'-四甲氧基木脂素、4,4'-二乙酰基-3,3'-二甲氧基木脂素、talaumidin、heliobuphthalmin、(-)-二氢-cubebin 和 hinokinin 被评估抑制人巨细胞病毒（HCMV）IE-抗原在肺癌细胞（A549）中的表达的能力。
大多数评估的化合物降低了 HCMV 的 IE-抗原表达，其中 4,4'-二羟基-3-甲氧基木脂素的效果最好。然而，(-)-二氢-cubebin 的衍生物发现 IE-抗原表达呈剂量依赖性显著增加。
本研究结果表明，其中一些木脂素可能作为潜在的癌症化学预防剂具有重要价值。
