Pusztai Rozália, Hohmann Judit, Rédei Dora, Engi Helga, Molnár Joseph
Department of Medical Microbiology and Immunobiology, University of Szeged, H-6720 Szeged, Hungary.
In Vivo. 2008 Nov-Dec;22(6):787-92.
The development of strategies intended to inhibit human cytomegalovirus (HCMV) immediate-early (IE) antigen expression is an important goal in research designed to prevent and treat certain forms of cancer. The aim of this study was to identify potent IE antigen-targeting natural compounds as antitumor promoters in an in vitro model of tumor promotion. Nineteen dihydro-beta-agarofuran sesquiterpenes isolated from Euonymus species were evaluated for their ability to inhibit HCMV IE antigen expression in human lung adenocarcinoma (A549) cells. Five esters of penta- and hexahydroxydihydro-beta-agarofuran proved to be active components in these Euonymus species, inhibiting the IE antigen expression of HCMV. The highest activity was displayed by 2beta,6alpha,15-triacetoxy1beta-benzoyloxy-9alpha-nicotinoyloxydihydro-beta-agarofuran. These effective compounds may be regarded as prototypes of antitumor promoters, as secondary chemopreventive agents which can modify or halt tumor promotion in general.
旨在抑制人类巨细胞病毒（HCMV）即刻早期（IE）抗原表达的策略开发，是预防和治疗某些癌症形式的研究中的一个重要目标。本研究的目的是在肿瘤促进的体外模型中，鉴定作为抗肿瘤促进剂的强效靶向IE抗原的天然化合物。对从卫矛属植物中分离出的19种二氢-β-agarofuran倍半萜进行了评估，以确定它们在人肺腺癌（A549）细胞中抑制HCMV IE抗原表达的能力。五羟基和六羟基二氢-β-agarofuran的五种酯被证明是这些卫矛属植物中的活性成分，可抑制HCMV的IE抗原表达。2β,6α,15-三乙酰氧基-1β-苯甲酰氧基-9α-烟酰氧基二氢-β-agarofuran表现出最高活性。这些有效化合物可被视为抗肿瘤促进剂的原型，作为一般可改变或阻止肿瘤促进的二级化学预防剂。
