Turk A S, Aagaard-Kienitz B, Niemann D, Consigny D, Rappe A, Grinde J, Strother C M
Departments of Radiology, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA.
AJNR Am J Neuroradiol. 2007 Mar;28(3):531-2.
The canine vein pouch aneurysm model is widely used for testing and development of devices directed at the endovascular treatment of aneurysms. Our purpose was to determine the incidence of spontaneous thrombosis and rupture of these aneurysms.
A retrospective review of laboratory records of canine vein pouch aneurysms made during a 6-year period was performed. The aneurysm and parent artery dimensions as well as incidences of spontaneous thrombosis and rupture were noted.
During the interval studied, 326 vein patch aneurysms were made in 310 canines. Of these, 102 were sidewall (lateral) and 224 were bifurcation aneurysms. Spontaneous occlusion occurred in 9 of the sidewall aneurysms and in only 1 of the bifurcation aneurysms. None of the aneurysms ruptured.
Spontaneous occlusion of the sidewall canine vein patch aneurysm occurred less than 10% of the time; in the bifurcation aneurysms, it almost never occurred. These characteristics enhance the value of this model for use in testing of devices intended for the endovascular treatment of aneurysms.
犬静脉囊状动脉瘤模型广泛用于针对动脉瘤血管内治疗器械的测试与研发。我们的目的是确定这些动脉瘤自发血栓形成和破裂的发生率。
对6年间制作的犬静脉囊状动脉瘤的实验室记录进行回顾性分析。记录动脉瘤及供血动脉的尺寸，以及自发血栓形成和破裂的发生率。
在研究期间，对310只犬制作了326个静脉补片动脉瘤。其中，102个为侧壁（外侧）动脉瘤，224个为分叉处动脉瘤。9个侧壁动脉瘤发生自发闭塞，而分叉处动脉瘤仅有1个发生自发闭塞。所有动脉瘤均未破裂。
侧壁犬静脉补片动脉瘤自发闭塞的发生率不到10%；在分叉处动脉瘤中，几乎从未发生。这些特性提高了该模型在测试用于动脉瘤血管内治疗器械方面的价值。
