Graves V B, Partington C R, Rüfenacht D A, Rappe A H, Strother C M
Department of Radiology, University of Wisconsin Clinical Science Center, Madison 53792.
AJNR Am J Neuroradiol. 1990 Mar-Apr;11(2):249-52.
The objectives of this study were to investigate the consistency, patency, and natural history of a vein graft canine aneurysm model and to determine the effectiveness of various coil designs on inducing aneurysm thrombosis. Twenty-one sacculuslike aneurysms were created in mongrel dogs by anastomosing a vein pouch to the common carotid artery. The model produced wide-neck aneurysms with 100% patency. The canine vein graft aneurysm provided an excellent model for the evaluation of endovascular devices. Three types of specially designed platinum coils were placed in the aneurysms: those with simple curves, those with complex curves, and those with flower petal curves and silk fibers. These coils were placed by the endovascular route by means of microcatheters. Flower petal coils with silk fibers were effective in producing thrombosis of the aneurysms, suggesting that coils of the appropriate design may be useful in the endovascular treatment of aneurysms. The other coil designs evaluated, those with simple and complex curves without silk fibers, demonstrated insufficient thrombogenicity and spatial stability.
本研究的目的是调查静脉移植犬动脉瘤模型的一致性、通畅性和自然病史，并确定各种线圈设计在诱导动脉瘤血栓形成方面的有效性。通过将静脉囊袋与颈总动脉吻合，在杂种犬中创建了21个囊状动脉瘤。该模型产生了宽颈动脉瘤，通畅率为100%。犬静脉移植动脉瘤为评估血管内装置提供了一个极好的模型。三种特殊设计的铂线圈被放置在动脉瘤中：具有简单曲线的线圈、具有复杂曲线的线圈以及具有花瓣曲线和丝纤维的线圈。这些线圈通过微导管经血管内途径放置。带有丝纤维的花瓣形线圈在产生动脉瘤血栓形成方面有效，这表明适当设计的线圈可能在动脉瘤的血管内治疗中有用。所评估的其他线圈设计，即没有丝纤维的简单和复杂曲线的线圈，显示出血栓形成能力不足和空间稳定性不足。
