Razinia Tannaz, Saver Jeffrey L, Liebeskind David S, Ali Latisha K, Buck Brian, Ovbiagele Bruce
Department of Neurology, UCLA Stroke Center, UCLA Medical Center, Los Angeles, CA 90095, USA.
Arch Neurol. 2007 Mar;64(3):388-91. doi: 10.1001/archneur.64.3.388.
Obesity is a risk factor for vascular disease and has been associated with poorer outcomes in hospitalized patients.
To evaluate the relationship between body mass index (BMI) (calculated as weight in kilograms divided by height in meters squared) and discharge outcomes among persons hospitalized for ischemic stroke.
The relationship between BMI and discharge outcomes was analyzed in 805 consecutive patients with ischemic stroke admitted to a university hospital stroke service. Patients were categorized into 4 BMI categories representing lean, overweight, and class I and class II obesity. Outcome measures analyzed included discharge functional activity, direct discharge to home, and length of hospital stay. The independent effect of BMI on outcome was evaluated with regression analysis, adjusting for other variables known to predict outcome after ischemic stroke.
Four hundred fifty-one individuals (56.0%) met study criteria. Mean age was 65 years, and 28.0% were men. In multivariate analysis, the highest BMI category (compared with lowest BMI category) was associated with the least likelihood of being discharged directly home from the hospital stroke service (26% vs 45%, P = .04), and the upper 2 BMI categories (compared with lowest BMI category) were associated with a trend toward extended length of hospital stay (6.3 vs 5.2 days, P = .08). No significant differences in the functional activity outcome were noted across BMI categories.
Elevated BMI is associated with a lower likelihood of being discharged home and a trend toward extended hospital stay among patients hospitalized for ischemic stroke. Body mass index at hospital admission had no relation to discharge functional activity after stroke.
肥胖是血管疾病的一个危险因素，并且与住院患者较差的预后相关。
评估体重指数（BMI，计算方法为体重千克数除以身高米数的平方）与因缺血性卒中住院患者出院结局之间的关系。
对一家大学医院卒中服务中心收治的805例连续性缺血性卒中患者的BMI与出院结局之间的关系进行了分析。患者被分为4个BMI类别，分别代表消瘦、超重、I类肥胖和II类肥胖。分析的结局指标包括出院时的功能活动、直接出院回家以及住院时间。采用回归分析评估BMI对结局的独立影响，并对已知可预测缺血性卒中后结局的其他变量进行校正。
451例个体（56.0%）符合研究标准。平均年龄为65岁，男性占28.0%。在多变量分析中，最高BMI类别（与最低BMI类别相比）与从医院卒中服务中心直接出院回家的可能性最小相关（26%对45%，P = 0.04），BMI最高的2个类别（与最低BMI类别相比）与住院时间延长的趋势相关（6.3天对5.2天，P = 0.08）。不同BMI类别之间在功能活动结局方面未观察到显著差异。
BMI升高与因缺血性卒中住院患者出院回家的可能性较低以及住院时间延长的趋势相关。入院时的体重指数与卒中后的出院功能活动无关。
