Uzoni Adriana, Ciobanu Ovidiu, Sandu Raluca Elena, Buga Ana Maria, Popa-Wagner Aurel
Department of Psychiatry, University of Medicine Rostock, Germany.
Biochemistry Department, University of Medicine and Pharmacy "Victor Babes", Timisoara, Romania.
Discoveries (Craiova). 2015 Mar 31;3(1):e39. doi: 10.15190/d.2015.31.
Cerebrovascular diseases represent 2nd leading cause of death worldwide. Understanding how genetic predispositions and their interaction with environmental factors affect cerebrovascular diseases is fundamental for prevention, diagnosis and for the development of safe and efficient therapies. Cerebrovascular diseases have not only a very high mortality rate, but also results in debilitating neurological impairments or permanent disability in survivors associated with huge economic losses. Among the women and men individuals with a low-risk lifestyle (smoking, exercising daily, consuming a prudent diet including moderate alcohol and having a healthy weight during mid-life) had a significantly lower risk of stroke than individuals without a low-risk lifestyle. Current review focuses on determining the relationship between diet, as an important component of 'life style', aging and cerebrovascular diseases.This review may help to unravel biological mechanisms linking lifestyle, diet-induced, metabolic inflammation, aging and cerebral hypoperfusion to development of cerebrovascular diseases, a prerequisite for development of science-based preventive strategies needed to combat the major public health challenges like obesity and stroke.
脑血管疾病是全球第二大死因。了解遗传易感性及其与环境因素的相互作用如何影响脑血管疾病，对于预防、诊断以及开发安全有效的治疗方法至关重要。脑血管疾病不仅死亡率极高，还会导致幸存者出现使人衰弱的神经损伤或永久性残疾，并带来巨大的经济损失。在拥有低风险生活方式（不吸烟、每日锻炼、饮食合理包括适量饮酒且中年时体重健康）的男性和女性个体中，中风风险显著低于没有低风险生活方式的个体。当前综述聚焦于确定作为“生活方式”重要组成部分的饮食、衰老与脑血管疾病之间的关系。本综述可能有助于揭示将生活方式、饮食诱导的代谢炎症、衰老和脑灌注不足与脑血管疾病发展联系起来的生物学机制，这是制定基于科学的预防策略的先决条件，这些策略对于应对肥胖和中风等重大公共卫生挑战至关重要。
