Bauters Tiene G M, Buyle Franky M A, Verschraegen Gerda, Vermis Karen, Vogelaers Dirk, Claeys Geert, Robays Hugo
Department of Pharmacy, University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium.
Pharm World Sci. 2007 Jun;29(3):122-5. doi: 10.1007/s11096-007-9105-3. Epub 2007 Mar 13.
To assess the incidence of postoperative wound infections related to treatment with medicinal leeches at Ghent University Hospital.
A 2-year retrospective analysis of bacteriologic culture results of soft tissue infections in patients treated with medicinal leeches.
Cultures of suspected wound infections were taken and susceptibility testing of isolates was performed on 17 of 47 patients (36.2%). Aeromonas was frequently isolated (18.5%).
A high incidence of infection during and after application of medicinal leeches, despite their external decontamination, necessitates an antibiotic prophylaxis. In particular Aeromonas must be covered, as soft tissue infections with these bacteria can give serious complications. The prophylactic antibiotic should cover the most frequent isolated species taking into account the importance of Aeromonas and the susceptibility pattern. Based on the results, fluoroquinolones seem to be a good choice. The authors believe that practical recommendations to hospital pharmacists on prophylaxis during Hirudo medicinalis treatment, might enhance the safety of it's use by reducing the number of infections.
评估根特大学医院使用药用水蛭治疗后手术伤口感染的发生率。
对接受药用水蛭治疗的患者软组织感染的细菌培养结果进行为期2年的回顾性分析。
对47例患者中的17例(36.2%)进行了疑似伤口感染培养及分离菌的药敏试验。气单胞菌分离率较高(18.5%)。
尽管药用水蛭经过外部消毒,但在应用期间及之后感染发生率较高,因此有必要进行抗生素预防。尤其必须覆盖气单胞菌,因为这些细菌引起的软组织感染可导致严重并发症。预防性抗生素应覆盖最常分离出的菌种,同时考虑气单胞菌的重要性和药敏模式。根据结果,氟喹诺酮类似乎是一个不错的选择。作者认为,向医院药剂师提供关于药用水蛭治疗期间预防的实用建议,可能会通过减少感染数量来提高其使用安全性。