1Department of Clinical Pharmacy, CHU de Montpellier, 371, Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.
2UMR 5569 HSM, Team "Pathogènes Hydriques Santé et Environnements", Unit of Bacteriology, Faculté de Pharmacie, Montpellier, France.
Antimicrob Resist Infect Control. 2018 Feb 5;7:19. doi: 10.1186/s13756-018-0311-7. eCollection 2018.
Leech therapy in plastic/reconstructive microsurgery significantly improves a successful outcome of flap salvage but the drawback is a risk of severe infection that results in a drop of the salvage rates from 70-80% to below 30%. We report the results of a national survey conducted in all the French university hospitals to assess the current extent of use of leech for medical practices in the hospital and to investigate maintenance, delivery practices and prevention of the risk of infection.
Data concerning conditions of storage, leech external decontamination, microbiological controls, mode of delivery and antibiotic prophylaxis were collected from all the French university hospitals in practicing leech therapy, on the basis of a standardized questionnaire.
Twenty-eight of the 32 centers contacted filled the questionnaire, among which 23 practiced leech therapy, mostly with a centralized storage in the pharmacy; 39.1% of the centers declared to perform leech external decontamination and only 2 centers recurrent microbiological controls of the water storage. Leech delivery was mostly nominally performed (56.5%), but traceability of the leech batch number was achieved in only 39.1% of the cases. Only 5 centers declared that a protocol of antibiotic prophylaxis was systematically administered during leech therapy: either quinolone (2), sulfamethoxazole/trimethoprim (2) or amoxicillin/clavulanic acid (1).
Measures to prevent infectious complications before application to patient have to be better applied and guidelines of good practices are necessary.
在整形/重建显微外科中,水蛭疗法显著提高了皮瓣挽救的成功率,但缺点是存在严重感染的风险,导致挽救率从 70-80%下降到 30%以下。我们报告了一项在所有法国大学医院进行的全国性调查结果,以评估目前在医院中使用水蛭的情况,并调查维持、交付实践以及感染风险的预防措施。
根据标准化问卷,从所有法国大学医院中从事水蛭疗法的医院收集了有关储存条件、水蛭外部消毒、微生物控制、交付方式和抗生素预防措施的数据。
联系的 32 个中心中有 28 个填写了问卷,其中 23 个中心实施了水蛭疗法,主要是在药房集中储存;39.1%的中心表示对水蛭进行外部消毒,只有 2 个中心对储水进行经常性的微生物控制。水蛭的交付主要是名义上进行的(56.5%),但只有 39.1%的情况下能追溯到水蛭批次号。只有 5 个中心表示在水蛭治疗期间系统地使用了抗生素预防方案:要么是喹诺酮类(2),要么是磺胺甲恶唑/甲氧苄啶(2),要么是阿莫西林/克拉维酸(1)。
在应用于患者之前,必须更好地采取预防感染性并发症的措施,有必要制定良好实践指南。