Strange Bryan A, Dolan Raymond J
Institute of Neurology, London, UK.
Cogn Neuropsychiatry. 2006 May;11(3):198-218. doi: 10.1080/13546800500305096.
To survive, an organism must remember occurrences of value in its environment. These include those that pose a threat to survival, novel or unexpected stimuli, or a general class of stimuli that represent punishment or reward. There is substantial evidence that memory for novel and emotionally salient events is enhanced relative to familiar or emotionally neutral events.
We present human functional magnetic resonance imaging (fMRI) experiments that address the neurobiological processes underlying upregulation of memory for novel or emotional events.
Enhanced memory for novel or unexpected stimuli is mediated by anterior hippocampus, whereas increased memory for emotional stimuli is mediated by a beta-adrenergic-dependent modulation of amygdala-hippocampal interactions. We introduce a hypothesis that medial temporal connectivity with autonomic control centres may be central to this memory enhancement.
Enhanced memory for stimuli that are of adaptive importance to survival is mediated by the anterior medial temporal lobe and effected via connections with the autonomic system.
为了生存，生物体必须记住其环境中具有价值的事件。这些事件包括对生存构成威胁的事件、新奇或意外的刺激，或代表惩罚或奖励的一般类别的刺激。有大量证据表明，相对于熟悉或情感中立的事件，对新奇和情感突出事件的记忆会增强。
我们展示了人类功能磁共振成像（fMRI）实验，这些实验探讨了对新奇或情感事件记忆上调背后的神经生物学过程。
对新奇或意外刺激的记忆增强由前海马体介导，而对情感刺激的记忆增加由杏仁核 - 海马体相互作用的β - 肾上腺素能依赖性调节介导。我们提出一个假设，即内侧颞叶与自主控制中心的连接可能是这种记忆增强的核心。
对生存具有适应性重要性的刺激的记忆增强由内侧颞叶前部介导，并通过与自主神经系统的连接实现。
