Strange B A, Hurlemann R, Dolan R J
Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom.
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13626-31. doi: 10.1073/pnas.1635116100. Epub 2003 Oct 31.
The influence of emotion on human memory is associated with two contradictory effects in the form of either emotion-induced enhancements or decrements in memory. In a series of experiments involving single word presentation, we show that enhanced memory for emotional words is strongly coupled to decrements in memory for items preceding the emotional stimulus, an effect that is more pronounced in women. These memory effects would appear to depend on a common neurobiological substrate, in that enhancements and decrements are reversed by propranolol, a beta-adrenergic antagonist, and abolished by selective bilateral amygdala damage. Thus, our findings suggest that amygdala-dependent beta-adrenergic modulation of episodic encoding has costs as well as benefits.
情绪对人类记忆的影响与两种相互矛盾的效应相关，即情绪诱发的记忆增强或记忆减退。在一系列涉及单个单词呈现的实验中，我们表明，对情感词汇的记忆增强与情感刺激之前项目的记忆减退紧密相关，这种效应在女性中更为明显。这些记忆效应似乎依赖于共同的神经生物学基础，因为增强和减退效应可被β-肾上腺素能拮抗剂普萘洛尔逆转，并被选择性双侧杏仁核损伤消除。因此，我们的研究结果表明，杏仁核依赖的β-肾上腺素能对情景编码的调节既有代价也有好处。
