Degott C, Feldmann G, Larrey D, Durand-Schneider A M, Grange D, Machayekhi J P, Moreau A, Potet F, Benhamou J P
Service d'Anatomie et de Cytologie Pathologiques, Hôpital Beaujon, Clichy, France.
Hepatology. 1992 Feb;15(2):244-51. doi: 10.1002/hep.1840150212.
Drug-induced acute hepatitis may be followed by prolonged cholestasis despite the withdrawal of the drug. Eight patients suffering from prolonged cholestasis caused by several drugs were investigated with sequential liver biopsies. At the early stage, lesions of acute cholangitis were observed in most patients; at the chronic phase, ductopenia, defined by the absence of interlobular bile ducts in at least 50% of small portal tracts, was demonstrated in all patients. Ductopenia might be the consequence of acute cholangitis; the degree of ductopenia and the chronicity of the disease might be directly related to the severity of the early acute damage of bile ducts. Consequently, in patients with severe cholestasis related to drugs, research of early morphological signs of acute cholangitis and then of ductopenia seems to be important.
药物性急性肝炎即便停用药物后仍可能继以长期胆汁淤积。对8例由多种药物引起长期胆汁淤积的患者进行了序贯肝活检研究。在早期，大多数患者观察到急性胆管炎病变；在慢性期，所有患者均表现为胆管减少，即至少50%的小门静脉区小叶间胆管缺如。胆管减少可能是急性胆管炎的后果；胆管减少的程度和疾病的慢性程度可能与早期胆管急性损伤的严重程度直接相关。因此，对于与药物相关的严重胆汁淤积患者，研究急性胆管炎的早期形态学征象进而研究胆管减少似乎很重要。
