Canesi M, Benti R, Marotta G, Cilia R, Isaias I U, Gerundini P, Pezzoli G, Antonini A
Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy.
Eur J Neurol. 2007 Mar;14(3):297-9. doi: 10.1111/j.1468-1331.2006.01642.x.
We used 123I-Ioflupane SPECT to study striatal dopamine transporter (DAT) binding in 36 Parkinson's disease (PD) patients with history of severe occupational exposure to hydrocarbons. Data were compared with 38 PD patients without exposure history as well as healthy controls. Both PD cohorts showed significant striatal uptake decrements compared with controls. We found significantly lower values in the whole striatum of exposed compared with non-exposed patients (0.83 +/- 0.25 vs. 1.05 +/- 0.39; P = 0.004), more pronounced in the putamen (0.61 +/- 0.24 vs. 0.85 +/- 0.42; P = 0.004). We conclude that severe occupational exposure to hydrocarbons may modify disease course and ultimately accelerate nigro-striatal denervation.
我们使用123I-碘氟烷单光子发射计算机断层扫描（SPECT）研究了36名有严重职业性碳氢化合物暴露史的帕金森病（PD）患者纹状体多巴胺转运体（DAT）结合情况。将数据与38名无暴露史的PD患者以及健康对照进行比较。与对照组相比，两个PD队列均显示出纹状体摄取显著减少。我们发现，与未暴露患者相比，暴露患者的整个纹状体值显著更低（0.83±0.25对1.05±0.39；P = 0.004），在壳核中更明显（0.61±0.24对0.85±0.42；P = 0.004）。我们得出结论，严重职业性碳氢化合物暴露可能改变疾病进程并最终加速黑质纹状体去神经支配。
