Polton G A, White R N, Brearley M J, Eastwood J M
Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Hitchin, Herts SG5 3HR, UK.
J Small Anim Pract. 2007 Mar;48(3):151-6. doi: 10.1111/j.1748-5827.2006.00187.x.
To determine the survival times for a cohort of dogs with insulinoma and to describe the impact of medical therapy both in non-surgical cases and in surgical cases following relapse.
A retrospective study of dogs with insulinoma is presented. The Kaplan-Meier method is used to evaluate the survival characteristics of this population.
Twenty-eight dogs were included in the study. The median survival time for all dogs was 547 days. Nineteen patients underwent partial pancreatectomy. The median survival time for this group was 785 days and for those subsequently receiving prednisolone therapy on relapse it was 1316 days. Perioperative complications are discussed.
Survival times in this study exceed those in other studies published previously. In part, this is explained by an improved remission duration following surgery compared with previous reports. More striking though is the longevity of patients following institution of medical therapy. These data give strong objective support to the role of medical therapy in the management of canine insulinoma, including following relapse after surgically induced remission.
确定一群患胰岛素瘤犬的存活时间，并描述药物治疗在非手术病例以及手术后复发病例中的作用。
对患胰岛素瘤犬进行一项回顾性研究。采用Kaplan-Meier方法评估该群体的存活特征。
28只犬被纳入研究。所有犬的中位存活时间为547天。19只犬接受了胰腺部分切除术。该组犬的中位存活时间为785天，复发后接受泼尼松龙治疗的犬的中位存活时间为1316天。讨论了围手术期并发症。
本研究中的存活时间超过了先前发表的其他研究。部分原因是与先前报告相比，手术后缓解期有所改善。然而，更显著的是药物治疗后犬的寿命延长。这些数据为药物治疗在犬胰岛素瘤管理中的作用提供了有力的客观支持，包括手术诱导缓解后复发的情况。
