Chase D, Bray J, Ide A, Polton G
Davies Veterinary Specialists, Manor Farm Business Park, Higham Gobion, Herts SG53HR.
J Small Anim Pract. 2009 Nov;50(11):568-74. doi: 10.1111/j.1748-5827.2009.00809.x. Epub 2009 Oct 8.
To define the outcome of a cohort of canine patients with a histological diagnosis of spindle cell tumour of soft tissue managed solely by surgery in first opinion practice.
Clinical details of 104 spindle cell sarcomas submitted to Finn Pathologists during the year 2000 were reviewed. Questionnaires were sent to the submitting veterinarians, requesting details about the tumour, surgery performed and ultimate outcome of the patient.
The method of surgical resection was described as marginal in 45 dogs (44.2 per cent). Excision margins of 3 cm or more were described in less than 10 per cent of cases. Tumours recurred locally in 29 dogs (27.9 per cent). Eighteen dogs (21.7 per cent) died of tumour-related causes. Most deaths were unrelated to sarcoma (50 dogs, 60.2 per cent) or unknown (15 dogs, 18 per cent). The median survival time was 1013 days. Tumour size, location or degree of surgical resection were not significantly related to survival or tumour recurrence. A palpable assessment of tumour invasion into underlying tissues was significantly associated with decreased disease-free interval (P<0.0001) and survival time (P = 0.0070).
The results of this retrospective study indicate that many spindle cell tumours managed in first opinion practice exhibit a low-grade biological behaviour and may respond well to more conservative surgery than current recommendations advise.
确定在初诊实践中仅通过手术治疗的组织学诊断为软组织梭形细胞瘤的犬类患者队列的预后情况。
回顾了2000年提交给芬兰病理学家的104例梭形细胞肉瘤的临床细节。向提交病例的兽医发送了问卷，询问有关肿瘤、所进行的手术以及患者最终结局的详细信息。
45只犬（44.2%）的手术切除方式被描述为边缘切除。不到10%的病例描述切缘为3厘米或更宽。29只犬（27.9%）出现局部肿瘤复发。18只犬（21.7%）死于与肿瘤相关的原因。大多数死亡与肉瘤无关（50只犬，60.2%）或原因不明（15只犬，18%）。中位生存时间为1013天。肿瘤大小、位置或手术切除程度与生存或肿瘤复发无显著相关性。对肿瘤侵犯深层组织的可触及评估与无病间期缩短（P<0.0001）和生存时间缩短（P = 0.0070）显著相关。
这项回顾性研究结果表明，在初诊实践中处理的许多梭形细胞瘤表现出低级别生物学行为，可能比当前建议对更保守的手术反应良好。
