Tobin R L, Nelson R W, Lucroy M D, Wooldridge J D, Feldman E C
Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Am Vet Med Assoc. 1999 Jul 15;215(2):226-30.
To compare outcome of surgical versus medical treatment of dogs with beta cell neoplasia.
Retrospective study.
39 dogs with clinical signs of hypoglycemia and serum glucose and insulin concentrations consistent with a diagnosis of beta cell neoplasia.
Information on signalment; clinical history; physical examination findings; results of CBC, serum biochemical analyses, and urinalysis; serum glucose and insulin concentrations; results of thoracic radiography and abdominal ultrasonography; treatment and treatment complications; survival time; and cause of death were obtained from medical records.
26 dogs underwent exploratory celiotomy and partial pancreatectomy; 13 dogs were treated medically (i.e., dietary change and prednisone). Median survival time was significantly longer for dogs treated surgically than for dogs treated medically. Significant differences were not found in mean age, body weight, duration of clinical signs prior to diagnosis, serum glucose and insulin concentration, or results of other serum biochemical tests between dogs treated surgically and dogs treated medically; also, there was no significant correlation between any of these parameters and survival time for either group of dogs.
Results suggest that exploratory celiotomy and partial pancreatectomy are indicated once a tentative diagnosis of beta cell neoplasia is established in dogs.
比较患有β细胞肿瘤的犬手术治疗与药物治疗的效果。
回顾性研究。
39只出现低血糖临床症状且血清葡萄糖和胰岛素浓度符合β细胞肿瘤诊断的犬。
从病历中获取有关特征、临床病史、体格检查结果、血常规、血清生化分析及尿液分析结果、血清葡萄糖和胰岛素浓度、胸部X线摄影及腹部超声检查结果、治疗及治疗并发症、生存时间和死亡原因的信息。
26只犬接受了剖腹探查术和部分胰腺切除术；13只犬接受了药物治疗（即饮食改变和泼尼松）。手术治疗的犬中位生存时间显著长于药物治疗的犬。手术治疗的犬与药物治疗的犬在平均年龄、体重、诊断前临床症状持续时间、血清葡萄糖和胰岛素浓度或其他血清生化检查结果方面未发现显著差异；此外，两组犬的这些参数与生存时间之间均无显著相关性。
结果表明，一旦在犬中初步诊断为β细胞肿瘤，就应进行剖腹探查术和部分胰腺切除术。
