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院前躯干升温方式治疗严重低体温症的比较研究:人体模型研究

Pre-hospital torso-warming modalities for severe hypothermia: a comparative study using a human model.

机构信息

Department of Anesthesia, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

出版信息

CJEM. 2005 Nov;7(6):378-86.

Abstract

OBJECTIVE

To compare 5 active torso-warming modalities in a human model of severe hypothermia with shivering heat production inhibited by intravenous meperidine.

METHODS

Six subjects were cooled on 6 different occasions each, in 8 degrees C water, for 30 minutes or to a core temperature of 35 degrees C. Spontaneous warming was the first torso-warming modality to be tested for every subject, and results served both as a comparative control and for determination of the meperidine dose for subsequent trials. Meperidine (1.5 mg/kg) was administered during the final 10 minutes of immersion to suppress shivering. Subjects were removed from the water, dried and insulated for 30 minutes, followed by 120 minutes of 1) forced-air warming with either a 600-W heater and commercial soft warming blanket; or 2) a 600-W heater and rigid cover; or 3) an 850-W heater and rigid cover; or 4) a charcoal heater on the chest; or 5) direct body-to-body contact with a normothermic partner. Supplemental meperidine (to a maximum cumulative dose of 3.2 mg/kg) was administered as required to inhibit shivering.

RESULTS

The initial post-cooling afterdrop was approximately 1.0 degrees C. After 30 minutes, core temperature continued to drop by 0.45 degrees C in spontaneous and body-to-body warming modalities. This post-warming afterdrop was significantly less with 600-W heater and rigid cover and the charcoal heater (0.26 degrees C) and the least with 850-W heater and rigid cover (0.17 degrees C). Core rewarming rates were highest using 850-W heater and rigid cover (1.45 degrees C/hr), with charcoal heating and 600-W rigid heater (0.7 degrees C/hr), 600-W heater and blanket (0.57 degrees C/hr) and body-to-body warming (0.52 degrees C/hr) being more effective than spontaneous warming (0.36 degrees C/hr).

CONCLUSIONS

In non-shivering subjects, external heat application was effective in attenuating core temperature afterdrop and facilitating safe core rewarming; this was more evident when heat was delivered preferentially to the chest, and dependent upon the amount of heat donated. The modalities studied appear sufficiently practical and portable for pre-hospital use and should be considered for such situations, particularly in rural or wilderness locations where anticipated transport time to the hospital exceeds 30 minutes.

摘要

目的

在使用静脉注射哌替啶抑制寒战产热的严重低体温人体模型中,比较 5 种主动躯干加热方式。

方法

在 8°C 的水中,6 名受试者在 6 个不同的场合各进行 30 分钟或直至核心体温降至 35°C。自发性升温是每个受试者首先接受的躯干升温方式,结果既是比较对照,也是确定随后试验中哌替啶剂量的依据。在浸入的最后 10 分钟内给予哌替啶(1.5mg/kg)以抑制寒战。受试者从水中取出,擦干并隔热 30 分钟,然后进行 120 分钟的以下 1)使用 600W 加热器和商业软加热毯的强制空气加热;或 2)600W 加热器和刚性盖;或 3)850W 加热器和刚性盖;或 4)胸部的木炭加热器;或 5)与正常体温的伴侣直接身体接触。根据需要给予补充哌替啶(最大累积剂量 3.2mg/kg)以抑制寒战。

结果

冷却后的初始后降约为 1.0°C。在 30 分钟后,自发和身体接触式升温方式的核心体温继续下降 0.45°C。600W 加热器和刚性盖以及木炭加热器(0.26°C)的后升温后降明显较少,850W 加热器和刚性盖(0.17°C)的后升温后降最少。使用 850W 加热器和刚性盖(1.45°C/hr)时,核心复温率最高,使用木炭加热和 600W 刚性加热器(0.7°C/hr)、600W 加热器和毯子(0.57°C/hr)以及身体接触式升温(0.52°C/hr)比自发升温(0.36°C/hr)更有效。

结论

在非寒战受试者中,外部热量应用可有效减轻核心温度后降并促进安全的核心复温;当热量优先传递到胸部时,这更为明显,并且取决于捐赠的热量量。所研究的方式在实践中似乎足够实用且便于携带,可用于院前使用,并且应在预计向医院转运时间超过 30 分钟的情况下考虑使用这些方式,特别是在农村或野外地区。

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