Wu Jun-Yan, Li Guo-Cheng, Wang Ding-Yong
Second Hospital of Sun yet-sen University, Guangzhou 510120, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2007 Feb;27(2):226-7.
To analyze the chemical constituents of the non-alkaloid fraction of Uncaria macrophylla.
The constituents were separated and purified by silica gel chromatography and recrystalization, and their structures were identified by infrared, mass and nuclear magnetic resonance spectrometry.
Six compounds were isolated from the non-alkaloid fraction of Uncaria macrophylla, whose structures were identified as beta-sitosterol, beta-daucosterol, ursolic acid, alpha-amyrin acetate, 3beta, 6beta, 23-trihydroxyurs-12-en-28-oic acid, 3beta-hydroxyurs-12-en-27, and 3beta-hydroxyurs-12-en-27, 28-dioic acid, respectively.
Ursolic acid is the main component in the non-alkaloid fraction of Uncaria macrophylla. Alpha-amyrin acetate and 3beta-hydroxyurs-12-en-27, 28-dioic acid are isolated and characterized for the first time from this plant.
分析大叶钩藤非生物碱部位的化学成分。
采用硅胶柱色谱和重结晶法对化合物进行分离纯化，通过红外光谱、质谱和核磁共振光谱鉴定其结构。
从大叶钩藤非生物碱部位分离得到6个化合物，其结构分别鉴定为β-谷甾醇、β-胡萝卜苷、熊果酸、α-香树脂醇乙酸酯、3β,6β,23-三羟基乌苏-12-烯-28-酸、3β-羟基乌苏-12-烯-27,28-二酸。
熊果酸是大叶钩藤非生物碱部位的主要成分。α-香树脂醇乙酸酯和3β-羟基乌苏-12-烯-27,28-二酸首次从该植物中分离得到并进行结构表征。
