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Intervirology. 2007;50(3):224-8. doi: 10.1159/000100565. Epub 2007 Mar 14.
2
Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism.经人类免疫缺陷病毒Tat处理的单核细胞通过肿瘤坏死因子相关凋亡诱导配体介导的机制杀死未感染的CD4(+)细胞。
J Virol. 2003 Jun;77(12):6700-8. doi: 10.1128/jvi.77.12.6700-6708.2003.
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Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells.I型人类免疫缺陷病毒tat的表达导致造血细胞中bcl-2的下调和细胞凋亡的诱导。
Oncogene. 1996 Aug 1;13(3):487-93.
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HIV-1 Tat protects CD4+ Jurkat T lymphoblastoid cells from apoptosis mediated by TNF-related apoptosis-inducing ligand.HIV-1反式激活因子可保护CD4+人Jurkat T淋巴母细胞免受肿瘤坏死因子相关凋亡诱导配体介导的细胞凋亡。
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Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: upregulation of trail in primary human macrophages by HIV-1 tat.鉴定T细胞中潜在的HIV诱导旁观者介导凋亡的来源：HIV-1反式激活因子上调原代人巨噬细胞中的肿瘤坏死因子相关凋亡诱导配体
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[Effect of HIV Tat protein on CCR5 expression in monocytes and infection with monocyte-tropic HIV strains].[HIV反式激活转录蛋白对单核细胞中CCR5表达及嗜单核细胞性HIV毒株感染的影响]
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2004 Nov;33(6):532-4, 545. doi: 10.3785/j.issn.1008-9292.2004.06.014.
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HIV type 1 Tat protein is a survival factor for Kaposi's sarcoma and endothelial cells.1型人类免疫缺陷病毒反式激活因子蛋白是卡波西肉瘤和内皮细胞的存活因子。
AIDS Res Hum Retroviruses. 2001 Jul 1;17(10):965-76. doi: 10.1089/088922201750290087.
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The human immunodeficiency virus type-1 Tat protein upregulates Bcl-2 gene expression in Jurkat T-cell lines and primary peripheral blood mononuclear cells.1型人类免疫缺陷病毒Tat蛋白上调Jurkat T细胞系和原代外周血单核细胞中Bcl-2基因的表达。
Blood. 1995 Nov 15;86(10):3823-34.

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本文引用的文献

1
The expression of CD154 by Kaposi's sarcoma cells mediates the anti-apoptotic and migratory effects of HIV-1-TAT protein.卡波西肉瘤细胞中CD154的表达介导了HIV-1-TAT蛋白的抗凋亡和迁移作用。
Int J Immunopathol Pharmacol. 2006 Jan-Mar;19(1):81-96.
2
Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism.经人类免疫缺陷病毒Tat处理的单核细胞通过肿瘤坏死因子相关凋亡诱导配体介导的机制杀死未感染的CD4(+)细胞。
J Virol. 2003 Jun;77(12):6700-8. doi: 10.1128/jvi.77.12.6700-6708.2003.
3
Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia.原发性B细胞慢性淋巴细胞白血病中对TRAIL诱导凋亡的耐药机制。
Oncogene. 2002 Oct 3;21(44):6809-18. doi: 10.1038/sj.onc.1205853.
4
HIV-1-Tat protein activates phosphatidylinositol 3-kinase/ AKT-dependent survival pathways in Kaposi's sarcoma cells.HIV-1-Tat蛋白激活卡波西肉瘤细胞中磷脂酰肌醇3激酶/AKT依赖的生存途径。
J Biol Chem. 2002 Jul 12;277(28):25195-202. doi: 10.1074/jbc.M200921200. Epub 2002 May 6.
5
Bcl-2 upregulation by HIV-1 Tat during infection of primary human macrophages in culture.在原代人巨噬细胞培养感染过程中，HIV-1反式激活蛋白（Tat）上调Bcl-2。
J Biomed Sci. 2002 Mar-Apr;9(2):133-9. doi: 10.1007/BF02256024.
6
Induction of cell death in human immunodeficiency virus-infected macrophages and resting memory CD4 T cells by TRAIL/Apo2l.TRAIL/Apo2l诱导人类免疫缺陷病毒感染的巨噬细胞和静息记忆性CD4 T细胞发生细胞死亡。
J Virol. 2001 Nov;75(22):11128-36. doi: 10.1128/JVI.75.22.11128-11136.2001.
7
Identification of a potential HIV-induced source of bystander-mediated apoptosis in T cells: upregulation of trail in primary human macrophages by HIV-1 tat.鉴定T细胞中潜在的HIV诱导旁观者介导凋亡的来源：HIV-1反式激活因子上调原代人巨噬细胞中的肿瘤坏死因子相关凋亡诱导配体
J Biomed Sci. 2001 May-Jun;8(3):290-6. doi: 10.1007/BF02256603.
8
Caspases: conductors of the cell death machinery in lymphoma cells.半胱天冬酶：淋巴瘤细胞中细胞死亡机制的执行者。
Leuk Lymphoma. 2001 Apr;41(3-4):247-53. doi: 10.3109/10428190109057980.
9
BCL-2 family members and the mitochondria in apoptosis.凋亡中的BCL-2家族成员与线粒体
Genes Dev. 1999 Aug 1;13(15):1899-911. doi: 10.1101/gad.13.15.1899.
10
Tat as one key to HIV-induced immune pathogenesis and Tat (correction of Pat) toxoid as an important component of a vaccine.Tat是HIV诱导免疫发病机制的关键因素之一，而Tat类毒素是疫苗的重要组成部分。 （注：原文中Pat有误，应为Tat）
Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8324-6. doi: 10.1073/pnas.96.15.8324.

HIV反式激活蛋白可增加单核细胞中Bcl-2的表达，从而抑制由肿瘤坏死因子-α相关凋亡诱导配体所诱导的单核细胞凋亡。

HIV Tat protein increases Bcl-2 expression in monocytes which inhibits monocyte apoptosis induced by tumor necrosis factor-alpha-related apoptosis-induced ligand.

作者信息

Zheng Lin, Yang Yida, Guocai Lu, Pauza C David, Salvato Maria S

机构信息

Department of Infectious Diseases, The First Affiliated Hospital, Medical School, Key Laboratory of Infectious Diseases of Chinese Ministry of Public Health, Zhejiang University, Hangzhou, Zhejiang, PR China.

出版信息

Intervirology. 2007;50(3):224-8. doi: 10.1159/000100565. Epub 2007 Mar 14.

DOI:10.1159/000100565
PMID:17356300
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2384232/
Abstract

OBJECTIVE

To investigate the effect of HIV Tat protein on Bcl-2 expression in human monocytes, and observe apoptosis of Tat-stimulated monocytes induced by TNF-alpha-related apoptosis-induced ligand (TRAIL).

METHODS

Western blot was used to detect Bcl-2 expression in monocytes stimulated by HIV Tat protein, and Annexin V and 7-AAD staining were used to detect apoptosis of monocytes induced by TRAIL.

RESULTS

HIV Tat protein increased Bcl-2 expression in human monocytes in a dose-dependent manner. Annexin V staining showed that 51.54% of monocytes underwent apoptosis after being treated with 100 ng/ml recombinant TRAIL. When monocytes were prestimulated with HIV Tat, only 15.46% of monocytes underwent apoptosis. This effect can be inhibited by polyclonal anti-Tat serum. 7-AAD staining showed similar results.

CONCLUSION

HIV Tat protein increases Bcl-2 expression in monocytes which inhibited apoptosis induced by TRAIL. HIV Tat protein may play an important role in the mechanisms of HIV-persistent infection in monocytes.

摘要

目的

研究HIV Tat蛋白对人单核细胞中Bcl-2表达的影响，并观察肿瘤坏死因子-α相关凋亡诱导配体（TRAIL）诱导的Tat刺激单核细胞的凋亡情况。

方法

采用蛋白质免疫印迹法检测HIV Tat蛋白刺激后单核细胞中Bcl-2的表达，采用膜联蛋白V和7-氨基放线菌素D染色法检测TRAIL诱导的单核细胞凋亡。

结果

HIV Tat蛋白以剂量依赖方式增加人单核细胞中Bcl-2的表达。膜联蛋白V染色显示，用100 ng/ml重组TRAIL处理后，51.54%的单核细胞发生凋亡。当单核细胞先用HIV Tat预刺激时，只有15.46%的单核细胞发生凋亡。这种效应可被多克隆抗Tat血清抑制。7-氨基放线菌素D染色显示了类似的结果。

结论

HIV Tat蛋白增加单核细胞中Bcl-2的表达，抑制TRAIL诱导的凋亡。HIV Tat蛋白可能在HIV在单核细胞中持续感染的机制中起重要作用。