Greany K A, Bonorden M J L, Hamilton-Reeves J M, McMullen M H, Wangen K E, Phipps W R, Feirtag J, Thomas W, Kurzer M S
Department of Food Science and Nutrition, University of Minnesota, St Paul, MN 55108, USA.
Eur J Clin Nutr. 2008 Feb;62(2):232-7. doi: 10.1038/sj.ejcn.1602719. Epub 2007 Mar 14.
To investigate the effect of probiotic capsules on plasma lipids.
A randomized, single-blinded, placebo-controlled, parallel-arm trial.
Fifty-five normocholesterolemic subjects ages 18-36 (33 premenopausal women and 22 men).
Each subject consumed either three probiotic capsules each containing a total of 10(9) colony-forming units Lactobacillus acidophilus and Bifidobacterium longum and 10-15 mg fructo-oligosaccharide or three placebo capsules daily for 2 months (men) or two menstrual cycles (women). Plasma lipids were measured before and following the intervention (during the early follicular phase for women).
Plasma concentrations of total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride were not altered by consumption of probiotic or placebo capsules and were not different between treatment groups following the intervention.
These results do not support a beneficial effect of Lactobacillus acidophilus strain DDS-1 and Bifidobacterium longum strain UABL-14 on plasma lipids in normocholesterolemic young women and men.
Supported by the Minnesota Agricultural Experiment Station and UAS Laboratories.
研究益生菌胶囊对血脂的影响。
一项随机、单盲、安慰剂对照、平行组试验。
55名年龄在18 - 36岁的血脂正常受试者（33名绝经前女性和22名男性）。
每位受试者每天服用3粒益生菌胶囊（每粒胶囊含有总共10⁹个嗜酸乳杆菌和长双歧杆菌菌落形成单位以及10 - 15毫克低聚果糖）或3粒安慰剂胶囊，持续2个月（男性）或两个月经周期（女性）。在干预前后（女性处于卵泡早期）测量血脂。
服用益生菌或安慰剂胶囊后，总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和甘油三酯的血浆浓度未发生改变，干预后各治疗组之间也无差异。
这些结果不支持嗜酸乳杆菌菌株DDS - 1和长双歧杆菌菌株UABL - 14对血脂正常的年轻女性和男性血脂有有益影响的观点。
由明尼苏达农业试验站和UAS实验室资助。
