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含有嗜酸乳杆菌和两歧双歧杆菌的益生菌酸奶对 2 型糖尿病患者血脂谱的影响。

Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus.

机构信息

Department of Food Science and Technology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

J Dairy Sci. 2011 Jul;94(7):3288-94. doi: 10.3168/jds.2010-4128.

Abstract

The purpose of this study was to investigate the effects of probiotic and conventional yogurt on the lipid profile in type 2 diabetic people. In a randomized double-blind controlled trial, 60 people (23 males and 37 females) with type 2 diabetes and low-density lipoprotein cholesterol (LDL-C) greater than 2.6 mmol/L were assigned to 2 groups. Participants consumed daily 300 g of probiotic yogurt containing Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 or 300 g of conventional yogurt for 6 wk. Fasting blood samples, anthropometric measurements and 3-d, 24-h dietary recalls were collected at the baseline and at the end of the trial. Probiotic yogurt consumption caused a 4.54% decrease in total cholesterol and a 7.45% decrease in LDL-C compared with the control group. No significant changes from baseline were shown in triglyceride and high-density lipoprotein cholesterol (HDL-C) in the probiotic group. The total cholesterol:HDL-C ratio and LDL-C:HDL-C ratio as atherogenic indices significantly decreased in the probiotic group compared with the control group. Probiotic yogurt improved total cholesterol and LDL-C concentrations in type 2 diabetic people and may contribute to the improvement of cardiovascular disease risk factors.

摘要

本研究旨在探讨益生菌和常规酸奶对 2 型糖尿病患者血脂谱的影响。在一项随机、双盲对照试验中,将 60 名(23 名男性和 37 名女性) 2 型糖尿病且低密度脂蛋白胆固醇(LDL-C)大于 2.6mmol/L 的患者分为两组。参与者每天食用 300g 含有嗜酸乳杆菌 La5 和双歧杆菌 Bb12 的益生菌酸奶或 300g 常规酸奶,持续 6 周。在基线和试验结束时采集空腹血样、人体测量学测量值和 3 天、24 小时膳食回忆。与对照组相比,益生菌酸奶可使总胆固醇降低 4.54%,使 LDL-C 降低 7.45%。益生菌组的甘油三酯和高密度脂蛋白胆固醇(HDL-C)无显著变化。与对照组相比,益生菌组的总胆固醇:HDL-C 比值和 LDL-C:HDL-C 比值作为致动脉粥样硬化指数显著降低。益生菌酸奶可改善 2 型糖尿病患者的总胆固醇和 LDL-C 浓度,并可能有助于改善心血管疾病的危险因素。

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