Roe Anna W
Department of Psychology, Vanderbilt University, Tennessee 37203, USA.
Appl Opt. 2007 Apr 1;46(10):1872-80. doi: 10.1364/ao.46.001872.
Some exciting new efforts to use intrinsic signal optical imaging methods for long-term studies in anesthetized and awake monkeys are reviewed. The development of such methodologies opens the door for studying behavioral states such as attention, motivation, memory, emotion, and other higher-order cognitive functions. Long-term imaging is also ideal for studying changes in the brain that accompany development, plasticity, and learning. Although intrinsic imaging lacks the temporal resolution offered by dyes, it is a high spatial resolution imaging method that does not require application of any external agents to the brain. The bulk of procedures described here have been developed in the monkey but can be applied to the study of surface structures in any in vivo preparation.
本文综述了一些令人兴奋的新研究成果，这些研究尝试利用内在信号光学成像方法对麻醉和清醒状态下的猴子进行长期研究。此类方法的发展为研究诸如注意力、动机、记忆、情感及其他高阶认知功能等行为状态打开了大门。长期成像对于研究伴随发育、可塑性和学习过程的大脑变化而言也是理想之选。尽管内在成像缺乏染料所提供的时间分辨率，但它是一种高空间分辨率成像方法，无需向大脑施加任何外部试剂。这里所描述的大部分程序是在猴子身上开发的，但可应用于任何活体标本表面结构的研究。
