嗅觉丧失可能是特发性帕金森病的首个症状。

Olfactory loss may be a first sign of idiopathic Parkinson's disease.

作者信息

Haehner Antje, Hummel Thomas, Hummel Cornelia, Sommer Ulrike, Junghanns Susann, Reichmann Heinz

机构信息

Department of Neurology, University of Dresden Medical School, Germany.

出版信息

Mov Disord. 2007 Apr 30;22(6):839-42. doi: 10.1002/mds.21413.

DOI:10.1002/mds.21413

PMID:17357143

Abstract

Recent studies support the idea of olfactory dysfunction as a very early sign of idiopathic Parkinson's disease (IPD). Aim of the present study was to clinically follow-up patients with idiopathic hyposmia to find out the percentage of patients developing IPD after 4 years time. At baseline, olfactory tests had been combined with transcranial sonography of the substantia nigra and (123)I-FP-CIT SPECT imaging. At the present neurological examination, 7% of the individuals with idiopathic hyposmia had developed clinical IPD. Altogether, 13% presented with abnormalities of the motor system. Our data suggest that a combination of olfactory testing and other tests may constitute a screening tool for the risk to develop IPD.

摘要

近期研究支持嗅觉功能障碍是特发性帕金森病（IPD）非常早期迹象的观点。本研究的目的是对特发性嗅觉减退患者进行临床随访，以查明4年后发展为IPD的患者百分比。在基线时，嗅觉测试已与黑质的经颅超声检查以及（123）I-FP-CIT单光子发射计算机断层扫描成像相结合。在目前的神经学检查中，7%的特发性嗅觉减退个体已发展为临床IPD。总体而言，13%的个体存在运动系统异常。我们的数据表明，嗅觉测试与其他测试相结合可能构成一种用于评估发展为IPD风险的筛查工具。