Intrathecal synthesis of soluble class I antigens in multiple sclerosis.
作者信息
Alvarez-Cermeño J C, Villar L M, Nocito M, Bootello A, González-Porqué P
机构信息
Department of Neurology, Hospital Ramón y Cajal, Madrid, Spain.
出版信息
J Neuroimmunol. 1992 Jan;36(1):77-9. doi: 10.1016/0165-5728(92)90032-g.
PMID:1735771
Abstract
We have studied the intrathecal synthesis of soluble class I antigens (sHLA), reflected by the index IH = (CSF sHLA/serum sHLA)/(CSF albumin/serum albumin), in multiple sclerosis (MS). IH was increased in patients in relapse, but normal in patients in remission; these findings show that there is a high lymphocyte activation within the central nervous system in patients with clinically active MS.
摘要
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