Fukuma Takeshi, Higgins Michael J, Jarvis Suzanne P
Centre for Research on Adaptive Nanostructures and Nanodevices, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland.
Phys Rev Lett. 2007 Mar 9;98(10):106101. doi: 10.1103/PhysRevLett.98.106101. Epub 2007 Mar 5.
Various metal cations in physiological solutions interact with lipid headgroups in biological membranes, having an impact on their structure and stability, yet little is known about the molecular-scale dynamics of the lipid-ion interactions. Here we directly investigate the extensive lipid-ion interaction networks and their transient formation between headgroups in a dipalmitoylphosphatidylcholine bilayer under physiological conditions. The spatial distribution of ion occupancy is imaged in real space by frequency modulation atomic force microscopy with sub-Angstrom resolution.
生理溶液中的各种金属阳离子与生物膜中的脂质头部基团相互作用，影响其结构和稳定性，但关于脂质-离子相互作用的分子尺度动力学却知之甚少。在此，我们直接研究了在生理条件下二棕榈酰磷脂酰胆碱双层中头部基团之间广泛的脂质-离子相互作用网络及其瞬时形成。通过具有亚埃分辨率的调频原子力显微镜在实空间中对离子占据的空间分布进行成像。
