Nguyen Johnny, Conca Dario Valter, Stein Johannes, Bovo Laura, Howard Chris A, Llorente Garcia Isabel
Department of Physics and Astronomy, University College London, London WC1E 6BT, United Kingdom.
London Centre for Nanotechnology, University College London, London WC1H 0AJ, United Kingdom.
Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2425-2434. doi: 10.1073/pnas.1817989116. Epub 2019 Jan 25.
Graphite is an inexpensive material with useful electrical, magnetic, thermal, and optical properties. It is also biocompatible and used universally as a substrate. Micrometer-sized graphitic particles in solution are therefore ideal candidates for novel lab-on-a-chip and remote manipulation applications in biomedicine, biophysics, chemistry, and condensed-matter physics. However, submerged graphite is not known to be amenable to magnetic manipulation, the optimal manipulation method for such applications. Here, we exploit the diamagnetism of graphite and demonstrate contactless magnetic positioning control of graphitic microflakes in diamagnetic aqueous solutions. We develop a theoretical model for magnetic manipulation of graphite microflakes and demonstrate experimentally magnetic transport of such particles over distances [Formula: see text] with peak velocities [Formula: see text] in inhomogeneous magnetic fields. We achieve fully biocompatible transport for lipid-coated graphite in NaCl aqueous solution, paving the way for previously undiscovered biomedical applications. Our results prove that micrometer-sized graphite can be magnetically manipulated in liquid media.
石墨是一种价格低廉的材料,具有有用的电学、磁学、热学和光学性质。它还具有生物相容性,被广泛用作基底。因此,溶液中的微米级石墨颗粒是生物医学、生物物理学、化学和凝聚态物理中新型芯片实验室和远程操纵应用的理想候选材料。然而,浸没在水中的石墨并不适合磁操纵,而磁操纵是此类应用的最佳操纵方法。在此,我们利用石墨的抗磁性,展示了在抗磁性水溶液中对石墨微片进行非接触式磁定位控制。我们开发了一个用于石墨微片磁操纵的理论模型,并通过实验证明了此类颗粒在非均匀磁场中能以峰值速度[公式:见原文]在距离[公式:见原文]上进行磁输运。我们在氯化钠水溶液中实现了脂质包覆石墨的完全生物相容性输运,为以前未被发现的生物医学应用铺平了道路。我们的结果证明,微米级石墨可以在液体介质中进行磁操纵。