Skubitz Keith M, Manivel J Carlos
Department of Medicine, University of Minnesota Medical School, and the Masonic Cancer Center, Minneapolis, MN 55455, USA.
BMC Cancer. 2007 Mar 14;7:46. doi: 10.1186/1471-2407-7-46.
Giant cell tumor (GCT) is usually a benign but locally aggressive primary bone neoplasm in which monocytic macrophage/osteoclast precursor cells and multinucleated osteoclast-like giant cells infiltrate the tumor. The etiology of GCT is unknown, however the tumor cells of GCT have been reported to produce chemoattractants that can attract osteoclasts and osteoclast precursors. Rarely, GCT can originate at extraosseous sites. More rarely, GCT may exhibit a much more aggressive phenotype. The role of chemotherapy in metastatic GCT is not well defined.
We report a case of an aggressive GCT of the uterus with rapidly growing lung metastases, and its response to chemotherapy with pegylated-liposomal doxorubicin, ifosfamide, and bevacizumab, along with a review of the literature.
Aggressive metastasizing GCT may arise in the uterus, and may respond to combination chemotherapy.
骨巨细胞瘤（GCT）通常是一种良性但具有局部侵袭性的原发性骨肿瘤，其中单核巨噬细胞/破骨细胞前体细胞和多核破骨细胞样巨细胞浸润肿瘤。GCT的病因尚不清楚，然而据报道GCT的肿瘤细胞可产生吸引破骨细胞和破骨细胞前体的趋化因子。GCT很少起源于骨外部位。更罕见的是，GCT可能表现出更具侵袭性的表型。化疗在转移性GCT中的作用尚不明确。
我们报告一例子宫侵袭性GCT伴快速生长的肺转移病例，及其对聚乙二醇化脂质体阿霉素、异环磷酰胺和贝伐单抗化疗的反应，并对相关文献进行综述。
侵袭性转移性GCT可能发生于子宫，且可能对联合化疗有反应。
