Hou Chun-sheng, Xu Zhi, Zhang Tong-lin, Peng Ying, Ling Xiao-feng, Wang Li-xin, Zhou Xiao-si
Department of General Surgery, Peking University Third Hospital, Beijing 100083, China.
Zhonghua Wai Ke Za Zhi. 2006 Dec 1;44(23):1620-3.
To explore the impact of different treatment procedure on the prognosis of T1 and T2 stage gallbladder cancer with the invasion within the gallbladder wall.
A retrospective analysis was conducted on 45 patients with pathologic stage T1 and T2 gallbladder cancer who had undergone surgical resection from 1990 and 2005.
Depth of invasion (T), radical cholecystectomy and postoperative adjuvant chemotherapy were independent prognostic factors on Cox multivariate analysis. The 5-year survival rates of patients with T1a, T1b and T2 stage gallbladder cancer who underwent simple cholecystectomy without postoperative adjuvant chemotherapy were 100%, 67% and 0, respectively. The survival rate in T2 was significantly lower than those in T1a and T1b. Without postoperative adjuvant chemotherapy, the 5-year survival rates of patients with T2 stage gallbladder cancer who underwent simple cholecystectomy and radical cholecystectomy were 0 and 63%, respectively. There was significant difference between the survival time of T2 patients who had undergone simple cholecystectomy with and without postoperative adjuvant chemotherapy.
The prognosis of patients with T1 stage gallbladder cancer is much better than that of T2 stage. The 5-year survival rates of patients with T1a and T1b stage gallbladder cancer who received simple cholecystectomy are relatively good. Radical cholecystectomy and postoperative adjuvant chemotherapy can improve the prognosis of patients with T2 gallbladder cancer.
探讨不同治疗方式对侵犯胆囊壁的T1和T2期胆囊癌预后的影响。
对1990年至2005年间接受手术切除的45例病理分期为T1和T2期的胆囊癌患者进行回顾性分析。
Cox多因素分析显示，浸润深度（T）、根治性胆囊切除术及术后辅助化疗是独立的预后因素。未行术后辅助化疗的单纯胆囊切除术患者中，T1a、T1b和T2期胆囊癌患者的5年生存率分别为100%、67%和0。T2期患者的生存率显著低于T1a和T1b期患者。未行术后辅助化疗时，T2期胆囊癌患者行单纯胆囊切除术和根治性胆囊切除术的5年生存率分别为0和63%。T2期患者行单纯胆囊切除术且术后未行辅助化疗与行辅助化疗患者的生存时间存在显著差异。
T1期胆囊癌患者的预后远优于T2期。行单纯胆囊切除术的T1a和T1b期胆囊癌患者5年生存率相对较好。根治性胆囊切除术及术后辅助化疗可改善T2期胆囊癌患者的预后。
