Rosenberg Ronald
Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80535, USA.
Trends Parasitol. 2007 May;23(5):193-6. doi: 10.1016/j.pt.2007.02.009. Epub 2007 Mar 13.
People who live in tropical Africa, south of the Sahara, are predominantly negative for the Duffy blood-group antigen, which mediates invasion of reticulocytes by Plasmodium vivax. Recent reports of a parasite that was molecularly diagnosed as P. vivax from populations who are suspected, or known, to be Duffy negative confound a large body of evidence that states that invasion of P. vivax requires the Duffy antigen. If confirmed, one of several possible explanations is that P. vivax, which originated in Asia, is now evolving to exploit alternate invasion receptors in Africa.
生活在撒哈拉以南热带非洲的人，杜菲血型抗原大多呈阴性，而该抗原介导间日疟原虫侵入网织红细胞。最近有报告称，在疑似或已知杜菲抗原呈阴性的人群中，分子诊断出一种寄生虫为间日疟原虫，这与大量表明间日疟原虫入侵需要杜菲抗原的证据相矛盾。如果得到证实，几种可能的解释之一是，起源于亚洲的间日疟原虫现在正在进化，以便在非洲利用其他入侵受体。
