Møller N, Schmitz O, Pørksen N, Møller J, Jørgensen J O
Medical Department M (Endocrinology and Diabetes), Aarhus Kommunehospital, Denmark.
Metabolism. 1992 Feb;41(2):172-5. doi: 10.1016/0026-0495(92)90147-3.
Whereas the lipolytic and diabetogenic consequences of sustained growth hormone (GH) exposure are well described, the metabolic effects of a short-lived physiological GH pulse have only recently been reported. To assess the possible dose-response of such short-term bolus administration of GH, six healthy, male subjects were each studied thrice for 4 1/2 hours after an intravenous (IV) bolus of either 70, 140, or 350 micrograms GH, resulting in peak GH concentrations of 10, 15, and 34 micrograms/L. Observed results include: (1) Time- (but not dose-) dependent changes (P less than .05) in plasma glucose and an acute (from 10 minutes onward), persistent, 40% decrease in forearm glucose uptake. Total glucose turnover decreased steadily with time on all occasions. (2) Time- and dose-dependent increases (P less than .05) in the concentrations of circulating lipid intermediates, with an increase of 3-hydroxybutyrate (3-OHB) from a basal of 35 mumol/L to peak values of 108 +/- 34 (70 micrograms), 176 +/- 46 (140 micrograms), and 232 +/- 51 mumol/L (350 micrograms), forearm uptake of 3-OHB changed in parallel. (3) Respiratory exchange ratio decreased (P less than .05) with increasing GH doses (indicating increased lipid and decreased glucose oxidation), and energy expenditure remained unaffected. (4) Concentrations of insulin, C-peptide, and glucagon were unchanged throughout all studies. We conclude that the stimulating effects of a modest GH bolus on circulating lipid intermediates and lipid oxidation are dose-dependent. This finding underlines the potential role of GH as a principal physiological regulator of fuel consumption in the maintenance of metabolic homeostasis.
虽然持续暴露于生长激素（GH）所产生的脂解和致糖尿病后果已有详尽描述，但短期生理性GH脉冲的代谢效应直到最近才被报道。为评估这种短期大剂量注射GH可能的剂量反应，对6名健康男性受试者每人进行了3次研究，在静脉注射70、140或350微克GH后，观察4个半小时，结果导致GH峰值浓度分别为10、15和34微克/升。观察结果包括：（1）血浆葡萄糖呈时间（而非剂量）依赖性变化（P<0.05），前臂葡萄糖摄取从10分钟起急剧下降并持续存在，下降了40%。在所有情况下，总葡萄糖周转率均随时间稳步下降。（2）循环脂质中间体浓度呈时间和剂量依赖性增加（P<0.05），3-羟基丁酸（3-OHB）从基础值35微摩尔/升增加到峰值，分别为108±34（70微克）、176±46（140微克）和232±51微摩尔/升（350微克），前臂对3-OHB的摄取也呈平行变化。（3）随着GH剂量增加，呼吸交换率下降（P<0.05）（表明脂质氧化增加而葡萄糖氧化减少），能量消耗未受影响。（4）在所有研究过程中，胰岛素、C肽和胰高血糖素的浓度均未改变。我们得出结论，适度剂量的GH脉冲对循环脂质中间体和脂质氧化的刺激作用是剂量依赖性的。这一发现强调了GH作为维持代谢稳态中燃料消耗主要生理调节因子的潜在作用。
