对自身抗原的先天反应会显著加剧烧伤创面深度。
Innate response to self-antigen significantly exacerbates burn wound depth.
作者信息
Suber Freeman, Carroll Michael C, Moore Francis D
机构信息
Harvard Medical School, Boston, MA 02115, USA.
出版信息
Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3973-7. doi: 10.1073/pnas.0609026104. Epub 2007 Feb 28.
Abstract
A major component of burn injury is caused by additional local damage from acute inflammation. Using a scald burn model in mice, we find that this part of the injury is dependent on recognition of self-antigen by specific natural IgM, leading to activation of the complement system. We propose that the depth of a burn wound is a sum of the thermal energy applied and of the degree of host inflammatory response.
摘要
烧伤损伤的一个主要组成部分是由急性炎症引起的额外局部损伤。通过在小鼠中使用烫伤模型，我们发现这部分损伤依赖于特定天然IgM对自身抗原的识别，从而导致补体系统的激活。我们提出，烧伤创面的深度是所施加热能与宿主炎症反应程度的总和。
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