Tsushima K, Koizumi T, Tanabe T, Nakagawa R, Yoshikawa S, Yasuo M, Kubo K
First Department of Internal Medicine, School of Medicine, Shinshu University, 3-1-1 Asahi Matsumoto Nagano 390-8621, Japan.
Eur Respir J. 2007 Jun;29(6):1193-200. doi: 10.1183/09031936.00111306. Epub 2007 Mar 14.
The aim of the current study was to assess the safety of bronchoscopy-guided radiofrequency ablation (RFA) and compare the effectiveness between new internal cooled-RFA and standard noncooled-RFA. Normal lungs from sheep were used (n=6). Internal cooled-RFA and standard noncooled-RFA were set to assess the most suitable RFA conditions, such as power output, flow rate and ablation time. Internal cooled-RFA was then applied under the most optimal conditions of power output and flow rate for 15, 30, 60 and 120 s, and two water temperatures either room temperature (RT) water or cold water. Criteria for the most appropriate conditions were set over 15 s of ablation time and 50 degrees C of the tip's temperature. Internal cooled-RFA had no complications. Standard noncooled-RFA was complicated with bronchial bleeding after RFA. On the basis of the histological findings, average temperature and average output, the most appropriate conditions of the cooled-RFA were a power output of 30 W and flow rate of 30 or 40 mL.min(-1). The cooled-RFA using cold water caused a smaller, more discrete, lesion compared with that using RT water. Bronchoscopy-guided internal cooled-radiofrequency ablation was an effective, safe and feasible procedure that could become a potential therapeutic tool in managing lung pathology.
本研究的目的是评估支气管镜引导下射频消融术（RFA）的安全性，并比较新型内部冷却式RFA与标准非冷却式RFA的有效性。使用绵羊的正常肺脏（n = 6）。设置内部冷却式RFA和标准非冷却式RFA以评估最适宜的RFA条件，如功率输出、流速和消融时间。然后在功率输出和流速的最优化条件下，分别以15、30、60和120秒的时间应用内部冷却式RFA，并使用两种水温，即室温（RT）水或冷水。将消融时间超过15秒且尖端温度达到50摄氏度设定为最适宜条件的标准。内部冷却式RFA未出现并发症。标准非冷却式RFA在RFA后出现支气管出血并发症。根据组织学结果、平均温度和平均输出，冷却式RFA的最适宜条件为功率输出30 W，流速30或40 mL·min⁻¹。与使用RT水相比，使用冷水的冷却式RFA造成的损伤更小、更离散。支气管镜引导下内部冷却式射频消融术是一种有效、安全且可行的手术方法，有望成为治疗肺部疾病的潜在工具。
