白细胞介素-12及辅助性T细胞1细胞因子在鼻窦黏液囊肿囊液中的表达
Expression of IL-12 and T helper cell 1 cytokines in the fluid of paranasal sinus mucoceles.
作者信息
Kariya Shin, Okano Mitsuhiro, Hattori Hisashi, Sugata Yuji, Matsumoto Rie, Fukushima Kunihiro, Akagi Hirofumi, Nishizaki Kazunori
机构信息
Department of Otolaryngology-Head and Neck Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
出版信息
Am J Otolaryngol. 2007 Mar-Apr;28(2):83-6. doi: 10.1016/j.amjoto.2006.06.017.
OBJECTIVE
The objective of this study was to assess the expression of regulatory cytokines and T helper cell (Th)1/Th2 cytokines in paranasal sinus mucoceles.
MATERIALS AND METHODS
Fluid samples of 12 paranasal sinus mucoceles were assessed by enzyme-linked immunosorbent assay for concentrations of regulatory cytokines (interleukin [IL]-10 and IL-12), Th1 cytokines (IL-2 and interferon gamma), and Th2 cytokines (IL-4 and IL-5).
RESULTS
IL-12 was detected in all samples, whereas IL-10 was detected in only one case. The concentration of IL-12 tended to correlate with that of interferon gamma and was significantly and positively correlated with that of IL-2.
CONCLUSIONS
Th1 cytokines and the Th1 regulatory cytokine IL-12, but not IL-10, potentially play a key role in the pathogenesis of paranasal sinus mucoceles. Together with our recent report showing that lipopolysaccharide is highly detected in mucocele fluid, the data from this study suggest that the Th1 response induced by lipopolysaccharide may affect the immunological inflammation in the epithelium of paranasal sinus mucoceles.
目的
本研究的目的是评估调节性细胞因子和辅助性T细胞（Th）1/Th2细胞因子在鼻窦黏液囊肿中的表达。
材料与方法
通过酶联免疫吸附测定法评估12例鼻窦黏液囊肿的液体样本中调节性细胞因子（白细胞介素[IL]-10和IL-12）、Th1细胞因子（IL-2和干扰素γ）以及Th2细胞因子（IL-4和IL-5）的浓度。
结果
所有样本中均检测到IL-12，而仅在1例样本中检测到IL-10。IL-12的浓度倾向于与干扰素γ的浓度相关，并且与IL-2的浓度显著正相关。
结论
Th1细胞因子和Th1调节性细胞因子IL-12而非IL-10可能在鼻窦黏液囊肿的发病机制中起关键作用。结合我们最近的报告显示黏液囊肿液中高度检测到脂多糖，本研究的数据表明脂多糖诱导的Th1反应可能影响鼻窦黏液囊肿上皮的免疫炎症。
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