Bergink Steven, Jaspers Nicolaas G J, Vermeulen Wim
MGC-CBG Department of Cell Biology and Genetics, Erasmus MC, P.O. Box 2040, 3000CA Rotterdam, The Netherlands.
DNA Repair (Amst). 2007 Sep 1;6(9):1231-42. doi: 10.1016/j.dnarep.2007.01.012. Epub 2007 Mar 23.
Like many other cellular processes, regulation of the DNA damage response (DDR) is regulated at different levels, ranging from transcriptional control to an array of distinct post-translational modifications. Involvement of ubiquitylation and the ubiquitin proteasome system in adjusting DDR are such protein modifications that were receiving increasing attention in the field. In this review we summarize and discuss a few recent key publications addressing the issue of DDR factor ubiquitylation, focusing on UV-induced DDR. We discuss the implications of these modifications to allow swift adaptation and regulation of genome surveillance factors.
与许多其他细胞过程一样，DNA损伤反应（DDR）的调节在不同水平上进行，从转录控制到一系列不同的翻译后修饰。泛素化和泛素蛋白酶体系统参与调节DDR，这些蛋白质修饰在该领域正受到越来越多的关注。在这篇综述中，我们总结并讨论了最近几篇关于DDR因子泛素化问题的关键出版物，重点关注紫外线诱导的DDR。我们讨论了这些修饰对基因组监测因子快速适应和调节的影响。
