Böhm Ingrid
Department of Radiology, University of Bonn, Sigmund-Feud Strasse 25, 53105, Bonn, Germany.
Clin Rheumatol. 2007 Nov;26(11):1877-82. doi: 10.1007/s10067-007-0597-y. Epub 2007 Mar 16.
The purpose was to find immunological disturbances in lupus erythematosus (LE) patients with concomitant malignancy. 159 LE patients have been analyzed. Routine laboratory analyses including screening of serum autoantibodies and analyzing peripheral blood mononuclear cells by using flow cytometry have been performed. Malignant diseases have been revealed in 12 (7.5%) cases. All patients suffered from internal malignancies. LE patients with vs without malignancy had significantly decreased anti-double stranded DNA (16.6 vs 31.6%; p < 0.05) and increased anti-SSA/SSB (83.3 vs 32.2%/26.4%; p < 3 x 10(-12)) antibodies. Patients with neoplastic disease had increased IgG within the cell nuclei (76.6% +/- 9.6 vs 51.8 +/- 4.6%; p < 2 x 10(-7)). IgG penetrating living cells has been shown previously in SLE but has so far not been found in association to LE patients with malignant disease.
目的是找出合并恶性肿瘤的红斑狼疮（LE）患者的免疫紊乱情况。对159例LE患者进行了分析。进行了常规实验室分析，包括血清自身抗体筛查和使用流式细胞术分析外周血单个核细胞。在12例（7.5%）患者中发现了恶性疾病。所有患者均患有内部恶性肿瘤。有恶性肿瘤和无恶性肿瘤的LE患者的抗双链DNA抗体显著降低（分别为16.6%和31.6%；p<0.05），而抗SSA/SSB抗体增加（分别为83.3%和32.2%/26.4%；p<3×10⁻¹²）。患有肿瘤疾病的患者细胞核内IgG增加（76.6%±9.6与51.8±4.6%；p<2×10⁻⁷）。此前在系统性红斑狼疮（SLE）中已显示IgG可穿透活细胞，但迄今为止尚未发现其与合并恶性疾病的LE患者有关。
