Nakao M, Karashima A, Katayama N
Biomodeling Lab, Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
Cell Mol Life Sci. 2007 May;64(10):1236-43. doi: 10.1007/s00018-007-6534-z.
Studies of regulatory mechanisms of sleep-wake rhythms have benefited greatly from mathematical modeling. There are two major frameworks of modeling: one integrates homeostatic and circadian regulations and the other consists of multiple interacting oscillators. In this article, model constructions based on these respective frameworks and their characteristics are reviewed. The two-process model and the multioscillator model are explained in detail. An appropriate mathematical abstraction is also shown to provide a viewpoint unifying the model structures, which might seem to be distinct. Recently acquired knowledge of neural regulatory mechanisms of sleep-wake rhythm has prompted modeling at the neural network level. Such a detailed model is also reviewed, and could be used to explore a possible neural mechanism underlying a pathological state of sleep-wake rhythm.
睡眠-觉醒节律调节机制的研究从数学建模中受益匪浅。有两个主要的建模框架：一个整合了稳态调节和昼夜节律调节，另一个由多个相互作用的振荡器组成。在本文中，将回顾基于这些各自框架的模型构建及其特点。详细解释了双过程模型和多振荡器模型。还展示了一种适当的数学抽象，以提供一个统一看似不同的模型结构的观点。最近获得的关于睡眠-觉醒节律神经调节机制的知识促使了神经网络层面的建模。这样一个详细的模型也将被回顾，并且可用于探索睡眠-觉醒节律病理状态背后可能的神经机制。
