Nakao M, Yamamoto M
Laboratory of Neurophysiology and Bioinformatics, Graduate School of Information Sciences, Tohoku University.
Nihon Rinsho. 1998 Feb;56(2):499-503.
So far, sleep researches have been improved by tight collaborations between behavioral and modeling studies. From the novel point of view, we developed the thermoregulatory model of sleep control, which reproduces the well-known features of human sleep-waking cycles. The biphasic daily pattern of sleepiness and the resulting behavior during sleep deprivation are mechanistically interpreted by reducing them into the behavior of the model elements. In addition, a physiological mechanism underlying REM (rapid eye movement sleep) regulation is modelled based on the recent physiological knowledge, which could be a novel explanation instead of the reciprocally interacting model of REM generation (McCarley et al, 1975). Our model successfully produces the limit cycle of REM-related neuronal activities.
到目前为止，行为研究与模型研究之间的紧密合作推动了睡眠研究的进展。从全新的视角出发，我们构建了睡眠控制的体温调节模型，该模型再现了人类睡眠 - 觉醒周期的著名特征。困倦的双相日模式以及睡眠剥夺期间产生的行为，通过将它们简化为模型元素的行为而得到了机制性的解释。此外，基于最新的生理学知识对快速眼动睡眠（REM）调节的生理机制进行了建模，这可能是一种全新的解释，而非REM产生的相互作用模型（麦卡利等人，1975年）。我们的模型成功地产生了与REM相关的神经元活动的极限环。
