Houthoofd Koen, Vanfleteren Jacques R
Department of Biology, Ghent University, K. L. Ledeganckstraat 35, 9000 Ghent, Belgium.
Mol Genet Genomics. 2007 Jun;277(6):601-17. doi: 10.1007/s00438-007-0225-1. Epub 2007 Mar 16.
Model organisms have been widely used to study the ageing phenomenon in order to learn about human ageing. Although the phylogenetic diversity between vertebrates and some of the most commonly used model systems could hardly be greater, several mechanisms of life extension are public (common characteristic in divergent species) and likely share a common ancestry. Dietary restriction, reduced IGF-signaling and, seemingly, reduced ROS-induced damage are the best known mechanisms for extending longevity in a variety of organisms. In this review, we summarize the knowledge of ageing in the nematode Caenorhabditis elegans and compare the mechanisms of life extension with knowledge from other model organisms.
为了了解人类衰老，模式生物已被广泛用于研究衰老现象。尽管脊椎动物与一些最常用的模式系统之间的系统发育差异可能再大不过了，但几种延长寿命的机制却是共通的（不同物种的共同特征），并且可能有着共同的起源。饮食限制、胰岛素样生长因子信号通路减弱以及似乎是活性氧诱导的损伤减少，是在多种生物中延长寿命的最知名机制。在这篇综述中，我们总结了线虫秀丽隐杆线虫衰老方面的知识，并将寿命延长机制与其他模式生物的相关知识进行了比较。
