Tjønneland Anne, Christensen Jane, Olsen Anja, Stripp Connie, Thomsen Birthe L, Overvad Kim, Peeters Petra H M, van Gils Carla H, Bueno-de-Mesquita H Bas, Ocké Marga C, Thiebaut Anne, Fournier Agnès, Clavel-Chapelon Françoise, Berrino Franco, Palli Domenico, Tumino Rosario, Panico Salvatore, Vineis Paolo, Agudo Antonio, Ardanaz Eva, Martinez-Garcia Carmen, Amiano Pilar, Navarro Carmen, Quirós José R, Key Tim J, Reeves Gillian, Khaw Kay-Tee, Bingham Sheila, Trichopoulou Antonia, Trichopoulos Dimitrios, Naska Androniki, Nagel Gabriele, Chang-Claude Jenny, Boeing Heiner, Lahmann Petra H, Manjer Jonas, Wirfält Elisabet, Hallmans Göran, Johansson Ingegerd, Lund Eiliv, Skeie Guri, Hjartåker Anette, Ferrari Pietro, Slimani Nadia, Kaaks Rudolf, Riboli Elio
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, 2100, Copenhagen Ø, Denmark.
Cancer Causes Control. 2007 May;18(4):361-73. doi: 10.1007/s10552-006-0112-9. Epub 2007 Feb 15.
Most epidemiologic studies have suggested an increased risk of breast cancer with increasing alcohol intake. Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer.
Incidence rate ratios (IRRs) based on Cox proportional hazard models were calculated using reported intake of alcohol, recent (at baseline) and lifetime exposure. We adjusted for known risk factors and stratified according to study center as well as potentially modifying host factors.
During 6.4 years of follow up, 4,285 invasive cases of breast cancer within the age group 35-75 years were identified. For all countries together the IRR per 10 g/day higher recent alcohol intake (continuous) was 1.03 (95% confidence interval (CI): 1.01-1.05). When adjusted, no association was seen between lifetime alcohol intake and risk of breast cancer. No difference in risk was shown between users and non-users of HRT, and there was no significant interaction between alcohol intake and BMI, HRT or dietary folate.
This large European study supports previous findings that recent alcohol intake increases the risk of breast cancer.
大多数流行病学研究表明，乳腺癌风险会随着酒精摄入量的增加而升高。利用参与欧洲癌症与营养前瞻性调查研究（EPIC）的274,688名女性的数据，我们研究了酒精摄入量与乳腺癌风险之间的关系。
基于Cox比例风险模型计算发病率比（IRR），使用报告的酒精摄入量、近期（基线时）和终生暴露量。我们对已知的风险因素进行了调整，并根据研究中心以及潜在的宿主因素进行分层。
在6.4年的随访期间，共识别出年龄在35至75岁之间的4,285例浸润性乳腺癌病例。对于所有国家，近期酒精摄入量每增加10克/天（连续变量）的IRR为1.03（95%置信区间（CI）：1.01 - 1.05）。调整后，未发现终生酒精摄入量与乳腺癌风险之间存在关联。激素替代疗法（HRT）使用者与非使用者之间的风险无差异，酒精摄入量与体重指数（BMI）、HRT或膳食叶酸之间也无显著交互作用。
这项大型欧洲研究支持了先前的研究结果，即近期酒精摄入量会增加乳腺癌风险。
