Bravo Dina, Machová Hana, Hahn Ales, Marková Hana, Otruba Lukás, Mandys Václav, Houstava Ladislav, Kalvach Pavel
Department of Neurology, Charles University, 3rd Medical Faculty and Faculty Hospital Královské Vinohrady, Prague, Czech Republic.
Acta Otolaryngol. 2007 Jan;127(1):93-7. doi: 10.1080/00016480500475583.
We present the clinical, radiological and pathological features of a case of a cranial hypertrophic pachymeningitis that developed in the course of mastoiditis and petrous apex inflammation and responded to immunosuppressive therapy only. Documented by the development of clinical findings, magnetic resonance imaging, cerebrospinal fluid changes, histopathology findings, by otosurgical intervention and finally by the insertion of a ventriculo-peritoneal shunt, the case illustrates a gradual development of pachymeningitis with consequent hydrocephalus and intracranial hypertension. We consider this disease development an example of immune-induced proliferative fibrotic changes in meninges.
我们报告了一例颅骨肥厚性硬脑膜炎的临床、影像学和病理学特征，该病例发生于乳突炎和岩尖炎病程中，仅对免疫抑制治疗有反应。通过临床症状的出现、磁共振成像、脑脊液变化、组织病理学结果、耳外科干预，以及最终脑室-腹腔分流术的实施得以证实，该病例说明了硬脑膜炎的逐渐发展以及随之而来的脑积水和颅内高压。我们认为这种疾病的发展是脑膜免疫诱导的增殖性纤维化改变的一个例子。
