Konidaris Socrates, Kouskouni Evangelia E, Panoskaltsis Theodore, Kreatsas Georgios, Patsouris Efstratios S, Sarivalassis Apostolos, Nonni Aphrodite, Lazaris Andreas C
2nd University Department of Obstetrics & Gynaecology, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Health Care Women Int. 2007 Feb;28(2):182-91. doi: 10.1080/07399330601128627.
HPV infection is by far the most frequent sexually transmitted disease. Our aim in this prospective nonrandomized study was to investigate the frequency with which different subtypes of the human papillomavirus (HPV) are found in gynaecological malignant and benign conditions and to compare the rate of infection between them. Detailed data of 195 women were selected and divided into three groups. The first group consisted of specimens from 68 women with cervical cancer. The second group consisted of specimens from 43 women with endometrial and ovarian cancer. The third group consisted of 84 specimens from women who were operated on for benign gynaecological diseases. Seven oncogenic types of HPV (6, 11 [low-risk subtypes] 16, 18, 31, 33, and 51 [high-risk subtypes]) were investigated by using the in situ hybridization technique. The HPV detection rate was higher in the cervical cancer group (74.8%), compared with the second (27.9%) and third (45.2%) groups. The most common HPV subtypes in the first group were 16 and 18. The most common subtypes in the second group were the 31, 33, and 51, and in the third group the 6 and 11 subtypes. Women developed cervical cancer at a younger age than endometrial or ovarian cancer. Smoking and exposure to multiple sexual partners appeared related to the development of cervical cancer. The use of contraceptive pill, dietary habits, and diabetes did not seem to increase the risk of HPV infection in this population. As it is common in other populations, in this selected population of Greek women we were able to confirm that in women with cervical cancer the most common HPV subtypes are 16 and 18. Education of adolescents on the epidemiological association of smoking and unprotected intercourse with cervical cancer will certainly help to reduce the rates of development of preinvasive and invasive cancer of the cervix in young women.
人乳头瘤病毒（HPV）感染是目前最常见的性传播疾病。在这项前瞻性非随机研究中，我们的目的是调查在妇科恶性和良性疾病中发现不同亚型人乳头瘤病毒（HPV）的频率，并比较它们之间的感染率。选取了195名女性的详细数据并分为三组。第一组由68名宫颈癌女性的标本组成。第二组由43名子宫内膜癌和卵巢癌女性的标本组成。第三组由84名因良性妇科疾病接受手术的女性的标本组成。采用原位杂交技术检测7种致癌型HPV（6、11[低风险亚型]、16、18、31、33和51[高风险亚型]）。与第二组（27.9%）和第三组（45.2%）相比，宫颈癌组的HPV检出率更高（74.8%）。第一组中最常见的HPV亚型是16和18。第二组中最常见的亚型是31、33和51，第三组中是6和11亚型。患宫颈癌的女性比患子宫内膜癌或卵巢癌的女性年龄更小。吸烟和有多个性伴侣似乎与宫颈癌的发生有关。在这一人群中，服用避孕药、饮食习惯和糖尿病似乎并未增加HPV感染风险。正如在其他人群中一样，在这一选定的希腊女性人群中，我们能够证实，宫颈癌女性中最常见的HPV亚型是16和18。对青少年进行吸烟和无保护性行为与宫颈癌的流行病学关联教育，肯定有助于降低年轻女性宫颈原位癌和浸润癌的发病率。
