Pathology Department, Dr. Lutfi Kirdar Kartal Research and Training Hospital, Cevizli, Istanbul, Turkey.
Med Oncol. 2013;30(3):597. doi: 10.1007/s12032-013-0597-5. Epub 2013 Jun 25.
Several studies have suggested a possible role of human papillomavirus (HPV) in the pathogenesis of endometrial carcinoma. The aim of the study was to investigate the presence of HPV DNA in endometrium cancers and nonneoplastic endometrium. Sixty endometrial adenocarcinomas with and without squamous differentiation and the nonneoplastic endometrium tissue of fifty-six of the same patients were analyzed for the presence of family 16 and family 6 HPV DNA by using chromogenic in situ hybridization technique on formalin-fixed and paraffin-embedded archival samples, and the results were confirmed by polymerase chain reaction method. HPV DNA was not detected either in the endometrial adenocarcinoma with or without squamous differentiation, or in the nonneoplastic endometrium tissue. It appears that HPV does not play any role in the pathogenesis of endometrial carcinoma, since endometrium may not to be a suitable host for HPV replication.
多项研究提示人乳头瘤病毒（HPV）可能在子宫内膜癌的发病机制中起作用。本研究旨在探讨 HPV DNA 在子宫内膜癌和非肿瘤性子宫内膜中的存在情况。采用显色原位杂交技术，对 60 例伴或不伴鳞化的子宫内膜腺癌及其中 56 例患者的非肿瘤性子宫内膜组织中 HPV 家族 16 和家族 6 DNA 进行检测，并对福尔马林固定石蜡包埋存档标本进行聚合酶链反应法验证，结果均未检测到 HPV DNA。HPV 似乎并未在子宫内膜癌或非肿瘤性子宫内膜组织中发挥作用，因为子宫内膜可能不是 HPV 复制的合适宿主。
