Zaffanello Marco, Franchini Massimo
Department of Pediatrics, University of Verona, Verona, Italy.
Hematology. 2007 Feb;12(1):69-73. doi: 10.1080/10245330600940048.
The main clinical features of nephrotic syndrome (NS) are heavy proteinuria, hypoalbuminemia, hyperlipidemia and edema. In addition, multiple abnormalities in the coagulation pathway may be a consequence of the NS. Both arterial and venous thromboembolic complications (TEC) are relatively common and serious consequences of NS. In addition, arterial and venous thrombosis might be unexpected events during an exacerbation of NS. Embolic episodes may manifest in different regions of the body such as the brain or the lung. Hence, predisposing factors, personal and family history of TEC, thrombosis location and evolution should be always investigated in children with NS.
肾病综合征（NS）的主要临床特征为大量蛋白尿、低白蛋白血症、高脂血症和水肿。此外，凝血途径的多种异常可能是NS的结果。动脉和静脉血栓栓塞并发症（TEC）都是NS相对常见且严重的后果。此外，动脉和静脉血栓形成可能是NS加重期间的意外事件。栓塞事件可能表现在身体的不同部位，如大脑或肺部。因此，对于患有NS的儿童，应始终调查其TEC的易感因素、个人和家族史、血栓形成部位及演变情况。
