Fontana Vincenzo, Horstman Lawrence L, Donna Elio, Dudkiewicz Pamela, Ahn Eugene R, Ahn Yeon S
Division of Hematology/Oncology, Wallace H Coulter Platelet Laboratory, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Hematology. 2007 Feb;12(1):75-80. doi: 10.1080/10245330600938281.
Platelets play an important role in inflammatory and immune responses. We report interstitial lung disease (ILD) developing during the acute phase of severe thrombocytopenia in 3 patients with severe refractory ITP.
We identified 3 cases with severe ITP who developed ILD in the course of refractory chronic ITP. The thrombocytopenia was severe in all cases. ILD was an incidental finding at the presentation and often misdiagnosed as lung infections. ILD was documented by lung biopsy in cases 1 and 2, supplemented by serial chest X-rays and/or CAT scan. As the ITP improved, ILD regressed in case 1, persisted in case 2, and progressed to advanced pulmonary fibrosis in case 3.
We report an association of ILD with severe refractory ITP. ILD was detected in acute phase of platelet destruction, suggesting that platelet destruction may have triggered inflammation in the lung, leading to ILD.
血小板在炎症和免疫反应中起重要作用。我们报告了3例严重难治性免疫性血小板减少症（ITP）患者在严重血小板减少的急性期发生间质性肺病（ILD）。
我们确定了3例严重ITP患者，他们在难治性慢性ITP病程中发生了ILD。所有病例的血小板减少都很严重。ILD在就诊时为偶然发现，常被误诊为肺部感染。病例1和病例2通过肺活检记录了ILD，并辅以系列胸部X线片和/或计算机断层扫描（CAT）。随着ITP病情改善，病例1的ILD消退，病例2持续存在，病例3进展为晚期肺纤维化。
我们报告了ILD与严重难治性ITP之间的关联。在血小板破坏的急性期检测到ILD，提示血小板破坏可能引发了肺部炎症，导致ILD。
