Kushima Hisako, Kinoshita Yoshiaki, Watanabe Kentaro, Takamatsu Yasushi, Ishii Hiroshi
Department of Respiratory Medicine, Fukuoka University Hospital, Japan.
Department of Hematology, Fukuoka University Hospital, Japan.
Intern Med. 2019 Nov 1;58(21):3083-3086. doi: 10.2169/internalmedicine.2664-19. Epub 2019 Jul 10.
Objective Chest physicians often encounter patients with interstitial pneumonia with autoimmune features. However, there have so far been few reports of patients presenting with concurrent immune thrombocytopenia (ITP) and interstitial pneumonia. The prevalence of interstitial pneumonia in patients with ITP is less well known. Methods We surveyed patients diagnosed with ITP and interstitial pneumonia at the departments of Hematology and Respiratory Medicine to evaluate the association between these diseases. Results Among 73 patients with ITP, 7 patients (9.6%) presented with interstitial pneumonia, including 4 patients (2%) who developed ITP in the course of 204 patients with interstitial pneumonia. All 7 patients were men. Four patients were positive for some autoantibodies. Two patients had autoimmune diseases other than ITP. There were significant differences in age and gender between the ITP patients with and without interstitial pneumonia. Conclusion The present study suggests the possibility that the development of ITP, other autoimmune diseases, and interstitial pneumonia may be mutually associated. Advanced age and male sex in ITP may be significant predisposing factors for interstitial pneumonia. Clinicians should be aware of the potential for the coexistence of these diseases.
目的 胸科医生经常会遇到具有自身免疫特征的间质性肺炎患者。然而，迄今为止，关于同时出现免疫性血小板减少症（ITP）和间质性肺炎的患者的报道很少。ITP患者中间质性肺炎的患病率尚鲜为人知。方法 我们对血液科和呼吸内科诊断为ITP和间质性肺炎的患者进行了调查，以评估这两种疾病之间的关联。结果 在73例ITP患者中，7例（9.6%）出现了间质性肺炎，其中4例（2%）在204例间质性肺炎患者病程中发生了ITP。所有7例患者均为男性。4例患者某些自身抗体呈阳性。2例患者除ITP外还患有自身免疫性疾病。有间质性肺炎和无间质性肺炎的ITP患者在年龄和性别上存在显著差异。结论 本研究提示ITP、其他自身免疫性疾病和间质性肺炎的发生可能相互关联。ITP患者中的高龄和男性可能是间质性肺炎的重要易感因素。临床医生应意识到这些疾病共存的可能性。
