Maclure M, Greenland S
Department of Epidemiology, Harvard School of Public Health, Boston, MA.
Am J Epidemiol. 1992 Jan 1;135(1):96-104. doi: 10.1093/oxfordjournals.aje.a116206.
Tests for overall trend, such as the Mantel extension test, are not tests for monotonic dose response. A survey of epidemiologic articles shows widespread misinterpretation of the Mantel extension test and overstatement of evidence for monotonic dose response when there are few exposed subjects. To properly evaluate the hypothesis that risk continues to increase with further increases in exposure, one must examine several statistics and estimates. Given sufficient data, nonparametric or polynomial regression analyses can provide more detailed dose-response information.
用于检验总体趋势的方法，如曼特尔扩展检验，并非用于检验单调剂量反应。一项对流行病学文章的调查显示，当暴露个体较少时，对曼特尔扩展检验存在广泛的误解，且对单调剂量反应证据的夸大。为了正确评估风险是否随着暴露的进一步增加而持续上升这一假设，必须检查多个统计量和估计值。在有足够数据的情况下，非参数或多项式回归分析可以提供更详细的剂量反应信息。
