Sadegholvad Abdolsamad, Afkhamizadeh Mojhgan, Ranjbar-Omrani Gholamhossein
Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Arch Iran Med. 2007 Apr;10(2):168-70.
BACKGROUND: Thyroid dysfunction is associated with changes in the appetite. Ghrelin can regulate feeding behavior. The aim of this study was to evaluate whether ghrelin plays a role in the appetite changes in different states of thyroid dysfunction. METHODS: The serum ghrelin levels were measured in 45 newly diagnosed hyperthyroid and 45 newly diagnosed hypothyroid patients before and after medical treatment. Forty-five healthy subjects were also studied as control group. RESULTS: The ghrelin levels did not change significantly in patients with hyperthyroidism or hypothyroidism before and after the treatment. The ghrelin levels were not different from those of the control group. CONCLUSION: Ghrelin is not likely to be the primary determinant of appetite changes in thyroid dysfunction.
背景：甲状腺功能障碍与食欲变化有关。胃饥饿素可调节进食行为。本研究的目的是评估胃饥饿素在甲状腺功能障碍不同状态下的食欲变化中是否起作用。 方法：对45例新诊断的甲状腺功能亢进患者和45例新诊断的甲状腺功能减退患者在药物治疗前后测定血清胃饥饿素水平。还研究了45名健康受试者作为对照组。 结果：甲状腺功能亢进或减退患者治疗前后胃饥饿素水平无明显变化。胃饥饿素水平与对照组无差异。 结论：胃饥饿素不太可能是甲状腺功能障碍时食欲变化的主要决定因素。
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