Altinova Alev E, Törüner Füsun B, Aktürk Müjde, Elbeğ Sehri, Yetkin Ilhan, Cakir Nuri, Arslan Metin
Department of Endocrinology and Metabolism, Gazi Medical University School of Medicine, Ankara, Turkey.
Horm Res. 2006;65(6):295-9. doi: 10.1159/000092603. Epub 2006 Apr 6.
Recent studies have revealed that circulating ghrelin levels seem to play a role in energy homeostasis. The effect of hyperthyroidism on ghrelin levels is not fully known.
Serum levels of ghrelin and its relationship with insulin resistance were evaluated in 48 patients with hyperthyroidism and 43 euthyroid healthy controls. Thyroid hormones, insulin, glucose, ghrelin levels and lipid parameters were measured in all subjects. Insulin sensitivity was determined using the homeostasis model assessment.
Serum ghrelin levels were significantly decreased in hyperthyroid patients than in controls (32.5 +/- 23.3 vs. 54.1 +/- 35.5 pg/ml, p < 0.001). Circulating ghrelin levels significantly correlated with age (r = -0.26, p = 0.01), fasting glucose (r = -0.21, p = 0.01), free triiodothyronine (r = -0.18, p = 0.04), free thyroxine (r = -0.23, p = 0.02) and thyroid stimulating hormone (r = 0.21, p = 0.04), but not with blood pressure, body mass index, lipid parameters, insulin and homeostasis model assessment (p > 0.05). Multiple regression analysis revealed glucose level to be the most important predictor of circulating ghrelin level.
These results indicate that hyperthyroidism has effect on serum ghrelin levels. Further studies are needed for the exact mechanism.
近期研究表明，循环中的胃饥饿素水平似乎在能量平衡中发挥作用。甲状腺功能亢进对胃饥饿素水平的影响尚不完全清楚。
对48例甲状腺功能亢进患者和43例甲状腺功能正常的健康对照者进行了胃饥饿素血清水平及其与胰岛素抵抗关系的评估。测量了所有受试者的甲状腺激素、胰岛素、血糖、胃饥饿素水平和血脂参数。采用稳态模型评估法测定胰岛素敏感性。
甲状腺功能亢进患者的血清胃饥饿素水平显著低于对照组（32.5±23.3对54.1±35.5 pg/ml，p<0.001）。循环中的胃饥饿素水平与年龄（r=-0.26，p=0.01）、空腹血糖（r=-0.21，p=0.01）、游离三碘甲状腺原氨酸（r=-0.18，p=0.04）、游离甲状腺素（r=-0.23，p=0.02）和促甲状腺激素（r=0.21，p=0.04）显著相关，但与血压、体重指数、血脂参数、胰岛素和稳态模型评估无关（p>0.05）。多元回归分析显示，血糖水平是循环中胃饥饿素水平的最重要预测因素。
这些结果表明甲状腺功能亢进对血清胃饥饿素水平有影响。确切机制还需要进一步研究。
