Department of Endocrinology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland.
Horm Metab Res. 2011 Feb;43(2):121-5. doi: 10.1055/s-0030-1269853. Epub 2010 Dec 16.
Using radioimmunoassay, the effects of thyroid hormones on plasma total ghrelin (Gh) and obestatin (Ob) concentrations were evaluated in thyrotoxic patients with an excess of thyroid hormones and in hypothyroid patients lacking endogenous thyroid hormones. 24 patients with thyrotoxicosis, 25 hypothyroid patents after total thyreoidectomy performed due to thyroid cancer, and 17 control subjects were examined. Compared with the controls, the ghrelin and obestatin were elevated in hypothyroidism, while they were decreased in thyrotoxicosis. The plasma Gh and Ob levels differ depending on the thyroid function. In thyroid hormones deficiency, plasma Gh and Ob are increased, while in patients with excess of thyroid hormones, the levels of both Gh and Ob are definitely lower. Gh/Ob ratio is higher in hypothyroidism than in control subjects and thyrotoxic patients.
采用放射免疫法检测甲状腺功能亢进患者甲状腺激素过多和甲状腺功能减退患者缺乏内源性甲状腺激素时血浆总胃饥饿素 (Gh) 和肥胖抑制素 (Ob) 浓度的变化。检查了 24 例甲状腺功能亢进症患者、25 例因甲状腺癌行甲状腺全切除术的甲状腺功能减退症患者和 17 例对照者。与对照组相比，甲状腺功能减退症时胃饥饿素和肥胖抑制素升高，而甲状腺功能亢进症时则降低。血浆 Gh 和 Ob 水平取决于甲状腺功能。甲状腺激素缺乏时，血浆 Gh 和 Ob 增加，而甲状腺激素过多的患者，Gh 和 Ob 的水平明显降低。甲状腺功能减退症患者的 Gh/Ob 比值高于对照组和甲状腺功能亢进症患者。
