Yassin Aksam A, Saad Farid
Clinic of Urology/Andrology, Segeberger Kliniken, Norderstedt-Hamburg, Germany.
J Sex Med. 2007 Mar;4(2):497-501. doi: 10.1111/j.1743-6109.2007.00442.x.
Late-onset hypogonadism is associated with relatively mild testosterone deficiencies. This study investigated the effects of restoring testosterone levels to normal in men with complaints of low sexual desire and erectile dysfunction.
Sexual function was assessed with the International Index of Erectile Function (IIEF) at baseline and after 24 weeks of testosterone administration.
Twenty-two hypogonadal men (mean age 58 years) with erectile dysfunction were studied. Fifteen patients had serum testosterone below 6.9 nmol/L, and seven between 7.2 and 11.7 nmol/L (reference values in our laboratory >/=12.0 nmol/L); there were considerable comorbidities. The duration of sexual complaints was on average 3.8 years. Patients received intramuscular long-acting testosterone undecanoate.
In all patients, serum testosterone levels were restored to normal within 6-8 weeks. Twelve patients reported a significant improvement in the sexual desire domain (from 4.5 to 8.4) and experienced an improvement in the erectile function domain (from 12 to 25 [Questions 1-5 plus 15)], following treatment with this long-acting testosterone; in 9 of 12 patients, this occurred only after at least 12-24 weeks. The remaining 10 patients reported an improvement of sexual desire (from 4.5 to 7.5), but no significant improvement in the erectile function domain (from 12 to 14). No changes in serum prostate-specific antigen or prostate volume were noticed while receiving this long-acting testosterone preparation.
Restoring testosterone levels to normal in men with proven subnormal testosterone levels improves libido in most subjects, and erectile function in more than 50% of these men. It may take 12-24 weeks before the effects of testosterone become manifest.
迟发性性腺功能减退与相对轻度的睾酮缺乏有关。本研究调查了在有性欲低下和勃起功能障碍主诉的男性中将睾酮水平恢复正常的效果。
在基线及睾酮给药24周后，使用国际勃起功能指数（IIEF）评估性功能。
研究了22名患有勃起功能障碍的性腺功能减退男性（平均年龄58岁）。15名患者血清睾酮低于6.9 nmol/L，7名患者血清睾酮在7.2至11.7 nmol/L之间（我们实验室的参考值≥12.0 nmol/L）；存在相当多的合并症。性主诉的持续时间平均为3.8年。患者接受肌肉注射长效十一酸睾酮。
所有患者的血清睾酮水平在6 - 8周内恢复正常。12名患者报告性欲领域有显著改善（从4.5提高到8.4），并且在接受这种长效睾酮治疗后勃起功能领域有改善（从12提高到25[问题1 - 5加15]）；在12名患者中的9名中，这种情况仅在至少12 - 24周后出现。其余10名患者报告性欲有所改善（从4.5提高到7.5），但勃起功能领域无显著改善（从12提高到14）。在接受这种长效睾酮制剂期间，未观察到血清前列腺特异性抗原或前列腺体积的变化。
在经证实睾酮水平低于正常的男性中将睾酮水平恢复正常，可改善大多数受试者的性欲，并使超过50%的男性勃起功能得到改善。睾酮的效果可能需要12 - 24周才会显现。
