Val-Bernal J Fernando, Rubio Susana, Garijo M Francisca, González-Vela M Carmen
Department of Anatomical Pathology, Marqués de Valdecilla University Hospital, Medical Faculty, University of Cantabria, Santander, Spain.
APMIS. 2007 Mar;115(3):254-8. doi: 10.1111/j.1600-0463.2007.apm_572.x.
Cellular angiofibroma (CAF) is a rare distinctive mesenchymal neoplasm that occurs almost exclusively in the genital area. We report the case of a 38-year-old woman who presented with an asymptomatic subcutaneous mass, 3.5 cm in diameter, located in the left hypochondrium, which had progressively enlarged during the previous 6 months. The lesion was completely excised. No recurrence was observed 3 months after the excision. A review of the literature--and including the present report--revealed five cases (three men and two women) with location outside the urogenital tract. Mean age was 57 (range 38-78) years; mean 41 years for women and 68 years for men. Average tumor size was 9 (range 3.5-25) cm; mean 5 cm for women and 12 cm for men. Tumors were located in the superficial soft tissue of the trunk, except for one case in the retroperitoneum. Mean follow-up was 29 (range 3-102) months, and no patient developed recurrence or metastasis. Extragenital CAF, except for location, shows similar clinicopathological features to genital CAF. Simple tumorectomy appears to be adequate treatment. Morphologically, CAF is closely related to spindle cell lipoma.
细胞性血管纤维瘤（CAF）是一种罕见的独特间叶性肿瘤，几乎仅发生于生殖器区域。我们报告一例38岁女性病例，该患者左季肋部出现一个无症状的皮下肿块，直径3.5 cm，在过去6个月中逐渐增大。病变被完整切除。切除后3个月未观察到复发。对文献（包括本报告）的回顾显示，有5例（3例男性和2例女性）病变位于泌尿生殖道外。平均年龄为57岁（范围38 - 78岁）；女性平均41岁，男性平均68岁。平均肿瘤大小为9 cm（范围3.5 - 25 cm）；女性平均5 cm，男性平均12 cm。肿瘤位于躯干浅表软组织，除1例位于腹膜后。平均随访29个月（范围3 - 102个月），无患者出现复发或转移。生殖器外CAF除位置外，显示出与生殖器CAF相似的临床病理特征。单纯肿瘤切除术似乎是充分的治疗方法。形态学上，CAF与梭形细胞脂肪瘤密切相关。
